MICEOSPIRA METCHNIKOVL 481 



into the peritoneal cavity of a guinea-pig of about 350 

 to 400 grammes weight. For larger animals more 

 material is used. If the material injected is from a 

 fresh culture of the cholera organism, toxic symp- 

 toms at once appear; these have their most pro- 

 nounced expression in depression of temperature, and 

 if one follows this decline in temperature from time to 

 time with the thermometer it will be seen to be gradual 

 and continuous from the time of injection to the death 

 of the animal (Pfeiifer 1 ), which occurs in from eighteen 

 to twenty-four hours after the operation. 



MICROSPIRA METCHNIKOVI (GAMALEIA), MIGULA, 

 1900. 



Synonym : Vibrio Metchnikovi, Gamaleia, 1888. 



A spirillum that simulates very closely the comma 

 bacillus of cholera in its morphological and cultural 

 peculiarities, but which is still easily distinguished from 

 it, is that described by Gamaleia 2 under the name of 



FIG. 79. 



r ' 

 ' ) 

 < 1 



C 



Microspira Metchnikovi from agar-agar culture, twenty-four hours' old. 



microspira Metchnikovi. It was found post mortem in a 

 number of fowls that had died in the poultry-market of 

 Odessa, and the experiments of the discoverer led him 



1 Loc. cit. 



Annales de 1'lustitut Pasteur, 1888, tome Ii., pp. 482, 552. 

 31 



