VOL. II.] PHILOSOPHICAL TRANSACTIONS. 203 



that are in the blood and the serosities. And indeed lean persons, and those 

 whose epiploon has been cut, are more subject than others to rheumatisms, lien- 

 teries, and the like diseases that are caused by the sharpness of the humours. 

 And those that are fat are not so easily seized on by them, because the acrimony 

 of the serosities is corrected by the mixture of the fat, just as the sharpest 

 lixivium will lose its force if oil be mingled therewith.* 



An Account of the Experiment of Transfusion, performed in London 

 Nov. 23, 1667, upon the Person of Arthur Coga^ at Arundel House, 

 in the Presence of many considerable and intelligent Spectators, 

 under the Management of Dr. Richard Lojfer and Dr. Ed- 

 MUND King ; by the latter of whom the Relation was drawn up. 

 N' 30, p. 557. 



The experiment of transfusion of blood into a human vein was made by us 

 in this manner : Having prepared the carotid artery in a young sheep, we in- 

 serted a silver pipe into the quills to let the blood run through it into a porrin- 

 ger, and in the space of almost a minute about 12 ounces of the sheep's blood 

 ran through the pipe into the porringer, which was somewhat to direct us in the 

 quantity of blood now to be transfused into the man. Which done, when we 

 came to prepare the vein in the man's arm, the vein seemed too small for that 

 pipe which we intended to insert into it ; so that we employed another about 

 one third part less at the little end. Then we made an incision in the vein, 

 after the method formerly published. No. 28, which method we observed with- 

 out any other alteration, but in the shape of one of our pipes, which we found 

 more convenient for our purpose. And having opened the vein in the man's 

 arm with as much ease as in the common way of venesection, we let thence 

 run out six or seven ounces of blood. Then we planted our silver pipe into the 

 said incision, and inserted quills between the two pipes already advanced in the 

 two subjects, to convey the arterial blood from the sheep into the vein of the 

 man. But this blood was near a minute before it had passed through the pipes 

 and quills into the arm ; and then it ran freely into the man's vein for the space 

 of two minutes at least ; so that we could feel a pulse in the said vein just be- 

 yond the end of the silver pipe; though the patient said he did not feel the 



♦ In many species of cachexy there is a rapid absorption and consumption of fat, whereby the acri- 

 mony existing in the fluids is considerably blunted, and tlie irritation on the nen'ous and arterial sys- 

 tems is proportionably lessened. 



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