PHILOSOPHICAL TRANSACTIONS. 511 



breadth, filled with a serous fluid, and producing a most violent burning sen- 

 sation; so as to be quite intolerable, inducing delirium, unless the contained 

 fluid was speedily let out. When the blisters were thus destroyed in one part, 

 they soon afterwards appeared in another. The girl was removed to the hos- 

 pital, where she had the assistance of all the physicians thereto belonging. After 

 resisting a course of demulcents, dissolvents, evacuants, &c.; the disorder 

 yielded at last to a mercurial salivation; and the patient was dismissed in March 

 1679, after 8 months of medical treatment, being directed to drink chalybeated 

 goat's milk. 



From this time she continued well until the 3d of January, l680, when the 

 vesicular eruption re-appeared. On the 5th she was admitted into the hospital 

 a second time; and it was again intended to have recourse to salivation, which 

 had before succeeded so well. In the mean while it was thought proper to 

 employ some preparatory remedies. During the use of which a sudden retro- 

 pulsion of the acrid humour from the surface to the interior, took place on the 

 1 5th, when all the blisters disappeared. Although this was a matter of rejoic- 

 ing to the patient, she being thereby freed from her excruciating pains, yet was 

 no good augured from it by her physicians, who apprehended the humour might 

 fall upon some important viscus ; to prevent which (as much as possible) some 

 discutient and diaphoretic medicines were prescribed. Five days afterwards, viz. 

 on the 20th, these apprehensions were seen to be too well founded; the patient 

 being seized with pains in the loins, bladder, perinceum, and inguina, accom- 

 panied with a prostration of strength, loss of appetite, symptoms of inflamma- 

 tion, suppression of urine, a quick and irregular pulse; from all which it was in- 

 ferred that nephritis had taken place. Accordingly recourse was had to vene- 

 section, emulsions, and an emollient and paregoric clyster; which to the asto- 

 nishment of every person came away by vomiting, in a quarter of an hour af- 

 terwards. The clyster being repeated it was again discharged by the mouth, 

 and along with it a number of small stones, to the quantity of half an ounce 

 in weight, but without having any faeces mixed with them. The warm bath 

 was prescribed, blisters were applied to the limbs (with a view to revulsion) and 

 anodynes and discutients to the loins and region of the pubes; venesection 

 was repeated (whereby the fever was abated) and laxative decoctions were given; 

 which last, however, as well as broths and whatever else she swallowed, were 

 vomited up ; and along with them a great number of small stones, as hard as 

 flint, together with broken pieces, resembling white marble both in colour 

 and hardness. Recourse was again had to clysters, which, as before, were dis- 

 charged upwards, and along with them an increased quantity of stones, which 

 in the preceding vomitings were not larger than peas, but now were as large as 



