558 PHILOSOPHICAL TRANSACTIONS. [aNNO 1722. 



of water. These 2 colours, green and yellow, have continued for whole months. 

 The bile became of a black colour, like ink, but soon fading by the affusion of 

 spirit of nitre. 



2d. The bile, taken from the gall-bladder of the bodies of those that died of 

 the plague, having been poured into a wound, made on purpose in different 

 dogs, rendered them presently melancholy, drowsy, and indifferent about food. 

 All these animals died in 3 or 4 days, with the essential marks of the true 

 plague ; as buboes, carbuncles, and gangrenous inflammations in the viscera, in 

 the same manner as in the human bodies from whence the bile was taken. 



3d. A drachm of the said pestiferous bilehavingbeen mixed with 2oz. of foun- 

 tain water, made lukewarm, and injected into the jugular vein of several dogs, 

 rendered them presently drowsy, and killed them in 4 hours, with gangrenous 

 inflammations, the heart stuffed full of black thick blood, the liver swelled, and 

 the gall-bladder full of green bile. 



4th. The same quantity of bile, injected by the crural vein, produced in the 

 dogs a heaviness in about an hour. They had such a strong loathing of their 

 food, that they would not eat or drink the least matter after the injection was 

 made. They frequently made water, especially if they were stirred. On the 

 3d day there appeared considerable tumors under the axilla, and on their thighs, 

 about 3 inches from the wound. The wound turned to a gangrene, and the 

 animal usually died on the 4th day, with all the signs of the plague. 



5th. A dog, at the hospital at the Mail, in Marseilles, who followed the 

 surgeons when they went to dress the sick, used greedily to swallow the cor- 

 rupted glands, and the dressings full of pus, taken off the plague-sores ; he 

 licked up the blood that he found spilt on the ground in the infirmary; and this 

 he did for about 3 months ; and yet he was always well, gay, brisk, full of play, 

 and familiar with all comers. We injected into the right crural vein of this dog 

 about a drachm of the pestiferous bile, mixed with 2 ounces of warm water. 

 He died the 4th day, as the others did, with a bubo on the wounded thigh ; on 

 which likewise there were two carbuncles, and the wound gangrened. What 

 was remarkable in this dog was, that after the injection, both when he was 

 living, and after he was opened, when dead, he had a very stinking smell, 

 which we did not observe in any of the others. He had also a considerable 

 haemorrhage from the wound, the night before he died, having struggled hard 

 to escape out of his confinement. 



6th. The 2d of May having injected about a drachm of human bile, taken 

 from persons dead of the plague, mixed with 2 ounces of warm water, into the 

 crural vein of a dog; he was presently drowsy, refused his food, and died about 



