5(56 PHILOSOPHICAL TRANSACTIONS. [aNNO 1722. 



way, when I was very well assured the quantity of matter received into the 

 vessels, could not amount to the 100th part of a grain. 



The persons inoculated have not been confined to any regimen, but only to 

 be kept moderately warm; and those who were grown up to live very temperate 

 and regular, to keep their minds easy and composed, and to use proper means 

 to drive away all fear and concern. Some have been obliged, from the time of 

 the incision, to abstain from flesh and all strong liquors; but I found afterwards, 

 that the eruption did not proceed so well, when they were obliged to live too 

 low. Perhaps in warmer climates, where they are not so much accustomed to 

 live upon flesh, such abstinence may be necessary ; but here I find it best to 

 let them eat and drink as usual, though something more sparingly, till the fever 

 begins to rise ; and then, but not before, we enjoin such a regimen as is usual 

 in like cases. 



The first thing that occurred after the incision, was the inflammation of 

 the wounds, which commonly happened about the 4th day, when they began to 

 appear very red round about, and to grow a little sore and painful ; in about 2 

 days more they began to digest and run. In some they begin to run sooner, 

 and the quantity discharged is much greater than in others. I generally found, 

 that in those who discharged most this way, the fever was more slight, and the 

 sraall-pox fewer, though I have known some do very well when these places 

 have only appeared very red, but have scarcely run any thing at all, as it usually 

 happens, when the incision is made so superficial as not to cut through the 

 skin. 



About the 7th day the symptoms of the fever begin to come on, which are 

 the very same, that we always observe in the small -pox of the distinct kind, in 

 the natural way. A quick pulse, great heat and thirst, pain in the head and 

 back, and about the region of the stomach, vomiting, doziness, starlings, 

 and sometimes convulsions. All were not seized with all these symptoms, nor 

 in the same degree or continuance ; some began on the 7th day, and continued 

 ill, without any remission, till after the 1 1th ; many not till the 8th or 9th day; 

 and the fever in these was more moderate, with great intermissions ; and some 

 have scarcely had any illness at all. During all this time the places of incision 

 continued to be very sore, and swell very much, so as to appear very large and 

 deep, and to discharge a great deal of matter. 



On the 10th day the small-pox most commonly appeared, sometimes on the 

 Qth, and sometimes not till the Uth : but I never found that any dift^erence of 

 age, constitution, or any other cause ever made them vary above I day from the 

 10th. The number was very different, in some not above 10 or 20, most 



