568 PHILOSOPHICAL TRANSACTIONS. [aNNO 17*22. 



In two instances the inoculation had no effect, the reason of which, in one, 

 was because the child had the small-pox before, as the parents believed, but the 

 distemper had been so favourable, as to leave it doubtful. In the other, the 

 matter was taken when the pustules were withered, and almost gone, and that 

 little moisture which they contained I suppose had lost its virtue; the boy on 

 whom it was used was no way affected; the places of incision did not at all in- 

 flame, nor swell as usual, nor did any pustules appear; but about a month after 

 he was seized with the distemper in the ordinary way, and did very well. 



Some of those who have been inoculated, that are grown up, have afterwards 

 attended others in the small-pox, and it has often happened that in families 

 where some children have been inoculated, others have been afterwards seized 

 in the natural way, and they have lain together in the same bed all the time; 

 but we have not yet found, that ever any had the distemper twice; neither is 

 there any reason to suppose it possible, there being no difference that can be 

 observed between the natural and artificial sort, but only that in the latter the 

 pustules are commonly fewer in number, and all the rest of the symptoms in 

 the same proportion more favourable. There is one observation which I have 

 made, though I would not yet lay any great stress on it, that in families where 

 any have been inoculated, those who have been afterwards seized, never had an 

 ill sort of small-pox, but always recovered very well. 



A further Account of inoculating the Small-pox^ By the same. N° 370, p. 49. 



I believe all other persons who have seen any thing of this practice are in the 

 same sentiment with us, and there is no doubt, but in a few years the world 

 will acknowledge the service which the Royal Society have done to mankind, 

 in first revealing to this part of Europe a thing so beneficial as it will certainly 

 prove ; for though some few unfortunate accidents may sometimes happen, yet 

 those will be very rare in comparison of the many sad and disastrous events 

 which this distemper has been, and ever will be very fruitful of, while it is 

 left to rage in its full force and violence. 



1 doubt not but when you have collected a sufficient number of observations 

 for it, you will be able to demonstrate, that the hazard in this method is very 

 inconsiderable, in proportion to that in the ordinary way by accidental conta- 

 gion; so small, that it ought not to deter any one from making use of it. In 

 order to satisfy myself what proportion the number of those that die of the 

 small-pox might bear to the whole number seized with the distemper in the 

 natural way, I have made some inquiry, as follows: In Halifax, since the be- 

 ginning of last winter, 27Q have had the small-pox, and out of that number 

 43 have died. In Rochdale, a small neighbouring market town, \77 have had 



