44 CORA SENNEE WINKIN 



5. It is impossible to influence the vascular response to anemia by 

 indiscriminate sections within the splanchnic outflow. In order defi- 

 nitely to abolish the response, it is necessary to section either suffi- 

 ciently far out in the periphery, or sufficiently high up in the spinal cord 

 to interrupt completely the continuity between the medulla and the 

 coeliac ganglion. 



6. The level at which the fibers of the splanchnic system leave the 

 spinal cord varies in different individuals. The greatest number of 

 fibers leave the cord in the lower thoracic, especially in the region of the 

 6th to 8th thoracic. However, constrictor fibers to the splanchnic 

 nerves leave the cord throughout the higher levels of the thoracic cord. 

 In certain individuals, fibers leaving as high as the 2nd and 3rd thor- 

 acic will maintain an appreciable level of blood pressure and activate 

 a significant anemic response. 



7. Cerebral occlusion, carried out in repeated succession, is borne 

 indefinitely (as many as 18 times) in intact animals. The occlusion 

 time is in no way curtailed and the anemic increment of blood pressure 

 only slightly diminished. 



8. The curve of the anemic rise under repeated cerebral occlusion 

 becomes dissociated into two distinct parts after eight or ten successive 

 occlusions have been inflicted. 



9. The long-continued maintenance of blood pressure at an extremely 

 high level, characteristic of the anemic rise, is no longer possible after 

 any gross interference with the supply of some product of adrenal 

 activity. 



10. An increased liberation of adrenalin under extreme splanchnic 

 stimulation cannot be demonstrated as necessary for the characteristic 

 contour of the anemic rise. This appears dependent on the amount of 

 circulating adrenalin. 



11. An increased availability of some product of adrenal activity 

 appears demonstrable in intact animals under extreme splanchnic stimu- 

 lation, after eight or ten successive occlusions have been inflicted. 



12. Survival after ligation of the adrenal glands may be reduced to 

 1 or 2 hours, when the animal is subjected to successive repeated cere- 

 bral occlusions. A complete failure of vasomotor tone seems demon- 

 strable in these animals. 



13. The response of the splanchnic nerves is dependent for its release 

 on conditions of functional activity within the brain stem. 



14. The vasomotor responses initiated by the splanchnic nerves of 

 the sympathetic nervous system are comparable with skeletal responses 



