OF KIDNEY AND LIVEK. 383 



cirrhosis and melanosis are due to the contractile tissue, as a 

 product of inflammatory action more or less acute. The 

 action of remedies, particularly of mercury, would appear to 

 corroborate this opinion. From the observations made on the 

 morbid anatomy of the human liver and kidney, I conclude 

 that certain of the diseases of those organs are due to the 

 development of new cells and new matter within the ducts 

 and nucleated cells of the organs, in accordance with the 

 normal laws of cellular development this cellular vegetation 

 at last destroying, more or less completely, the natural tissue 

 of the organ. 



APPENDIX TO PEECEDING PAPEE. 



[The following more detailed observations on the relation 

 of the secreting cells to the bile-ducts, and of the distribution 

 of the connective tissue in the liver, occur in a manuscript 

 essay, we believe unpublished, entitled " A General View of 

 the Healthy and Morbid Anatomy of the Liver." The obser- 

 vations on the relations of the cells and ducts are especially 

 interesting in connection with the recent descriptions of 

 Hering (Schultze's Archiv, 1867) and others on this subject, 

 whilst the careful description of the distribution of the areolar 

 texture, shows how thoroughly Professor Goodsir recognised 

 the importance of this tissue in its relations to the pathology 

 of the organ. There is no date attached to the essay, but from 

 the appearance of the paper and ink it had evidently been 

 written many years ago. EDS.] 



In the liver, as in every other gland, secretion is performed, 

 not by the vessels, but by the particles which form its paren- 

 chyma. In glands generally these particles are packed in the 

 form of a layer on the internal surface of the fine membrane 

 (germinal or primary membrane) of the ducts, from their open 



