VOL. XLIX.J PHILOSOPHICAL TRANSACTIONS. 6qI 



and Sir H. joined their purses to pay one of those who had it by inoculation in 

 Newgate, who was sent to Hertford, where the disease in the natural way was 

 epidemical and very mortal, and where this person nursed and lay in bed with 

 one, who had it, without receiving any new infection. 



To make a further trial, the late queen Caroline procured half a dozen of the 

 charity children belonging to St. James's parish, who were inoculated, and all of 

 them, except one (who had had the small-pox before, though she pretended not, 

 for the sake of the reward) went through it with the symptoms of a favourable 

 kind of that distemper. 



On these trials, and several others in private families, the late queen, then 

 princess of Wales, (who with the king always took most extraordinary, exemplary, 

 prudent and wise care of the health and education of their children) sent for Sir 

 H. to ask his opinion of the inoculation of the princesses. He told her royal 

 highness, that by what appeared in the several essays, it seemed to be a method 

 to secure people from the great dangers attending that distemper in the natural 

 way. That the preparations by diet, and necessary precautions taken, made that 

 practice very desirable ; but that not being certain of the consequences which 

 might happen, he would not persuade nor advise the making trials on patients of 

 such importance to the public. The princess then asked him, if he would dis- 

 suade her from it : to which he made answer, that he would not, in a matter so 

 likely to be of such advantage. Her reply was, that she was then resolved^ it* 

 should be done, and ordered him to go to the late King George the first, who 

 had commanded him to wait upon him on that occasion. He told his majesty 

 his opinion, that it was impossible to be certain but that raising such a commo- 

 tion in the blood, there might happen dangerous accidents not foreseen : to 

 which he replied, that such might and had happened to persons, who had lost 

 their lives by bleeding in a pleurisy, and taking physic in any distemper, let 

 ever so much care be taken. Sir H. told his majesty he thought this to be the 

 same case, and the matter was concluded on, and succeeded as usual, without 

 any danger during the operation, or the least ill symptom or disorder since. 



Sir H. had been consulted with on the like occasion by many, and was of opi- 

 nion, that since it is reckoned, that scarcely 1 in ] 000 misses having it some 

 time in their life, the sooner it is given them the better, notwithstanding the 

 heat of summer, or cold of winter; the danger being greater from falling into 

 the distemper naturally, than from the heat or cold of either. 



What he had observed, which he thought material, is not to inoculate such as 

 have any breakings out on their faces, soon after the measles, or any other oc- 

 casion, by which the small-pox were likely to be invited, and come in the face in 

 greater number, and so make the distemper more dangerous. Bleeding in ple- 

 thoras, or gentle clearing of the stomach and inte4>tines, are necessary; and ab- 



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