42 PROTEIN THERAPY 



the subject should be treated together with a number of related chemical 

 problems in an extended manner, the present treatise will not offer a suitable 

 opportunity. Jobling and Petersen have discussed some of the features 

 in a paper published in the Archives of Internal Medicine, where the litera- 

 ture will be found. It seems very probable that the iodids play a con- 

 siderable role in the stimulation of tissue, particularly in the enzyme 

 phenomena. Sherrick's and Sollmann's interesting observations on the 

 alteration of the reactivity of the skin to cutaneous injections, the reaction 

 of tuberculous patients (Petersen) and of carcinoma patients (Moresowa) 

 are but a few instances of this effect. The property of the iodids in in- 

 creasing the rate of diffusion of a number of substances in colloidal systems 

 evidently is closely related to their therapeutic effect. 



Turpentine. The use of turpentine for subcutaneous injections is 

 an old procedure that in a modified form has been very recently re- 

 introdnced in the treatment of skin diseases and inflammatory con- 

 ditions. Fochier in the early nineties had introduced the "Fixation 

 Abscess" as it was termed, produced by injecting about 1 c.c. of tur- 

 pentine subcutaneously and intramuscularly. The abscess was used 

 in certain acute infections, including pneumonia, puerperal fevers, 

 adnexal inflammation, etc. In many ways this was merely the re- 

 introduction of the very ancient method of producing an "issue" 

 by the use of seton or fontanelle. 



More recently the French and German clinicians have modified 

 this method and are now injecting minute quantities of turpentine 

 (20% of turpentine in olive oil) intramuscularly in frequently re- 

 peated doses. The mechanism involved is merely the production of a 

 multitude of small sterile areas of inflammation and necrosis, with 

 tissue stimulation from these foci. It is said to be used with suc- 

 cess in a number of skin diseases and the French observers have 

 used it extensively in the treatment of influenzal pneumonia, etc. 



According to Karo the turpentine mixture in olive oil 4 parts in 

 16 parts of olive oil is borne much better if one adds a sedative 

 such as eukupine. This lessens the pain at the site of injection. 

 Naturally care must be taken to avoid the subcutaneous tissues and 

 inject wholly intramuscularly. 



Karo has more recently recommended the use of "Terpichin." 

 This is absolutely free from rosins and oxids and is combined with 

 quinin which seems to increase its activity. The injections which 

 are similar to those of turpentine intragluteal and usually biweekly 

 are followed by a well marked general stimulation of the patient as 

 well as a leukocytosis. 



Antipyretics. The nonspecific effect plasmaactivation that re- 

 sults from the use of certain drugs has recently been studied by 

 Koniger. He has come to the conclusion that the antipyretics have 

 such an effect quite apart from the usual pharmacological effect here- 

 tofore studied, an effect which can be demonstrated if the dosage 



