58 



PROTEIN THERAPY 



two-phase curve did not occur, the increase being less in extent but 

 persisting for a longer period of time. (Fig. 1.) 



Concentration of the Lymph and Serum. The concentration of 

 the lymph proteins following the injection is considerably increased, 

 as determined by the Kjeldahl method for total protein nitrogen, 

 while the concentration of the nonprotein nitrogen may decrease. 



LYMPH FLOW 



5MINUTE TIME INTERVALS 



FIG. 1. Volume of lymph flow following Bacillus coli vaccine injection. 



The Leukocytes. Few of the changes following nonspecific ther- 

 apy have received the study or attention that the leukocytic reaction 

 has. The earliest workers with nonspecific methods of treatment fol- 

 lowed the leukocytic picture with great care, particularly because some 

 of the earlier methods the fixation abscess, yeasts, nuclein injections, 

 colloidal metals, etc. were developed at a time when clinicians began 

 to pay considerable attention to the leukocytic count. 



The role of the leukocyte in immune processes is by no means 

 an exhausted field of research; indeed it is one that in many ways 

 seems to offer an exceptionally attractive approach to innumerable 

 problems still obscure. Nageli in his "Blutkrankheiten" surmised that 

 a leukocytosis that resulted as an expression of an immune reaction 

 on the part of the bone marrow might be of decided therapeutic use. 

 Fiessinger and Marie have for many years emphasized the impor- 

 tance of the enzymes of the leukocytes in infectious disease while 

 the work of Metchnikoff and his pupils has so thoroughly covered 

 the general field of phagocytosis that it will be unnecessary to enter 



