146 PROTEIN THERAPY 



in conjunction with, not to the displacement of, other remedies. 



Cowie and Calhoun have made a very detailed and careful study 

 of a small series of arthritic cases that had proved intractable to 

 other forms of therapy, including 2 cases of chronic multiple peri- 

 arthritis deformans; one each of hypertrophic arthritis deformans, 

 chronic multiple periarthritis deformans, atrophic arthritis and hyper- 

 trophic spinal arthritis; two of acute rheumatism; two other cases 

 were treated, one a gonorrheal vulvovaginitis and the other a sup- 

 purative mastoiditis, complicated by chronic pulmonary tuberculosis. 

 Typhoid vaccine in relatively large dosage 1 billion organisms- 

 was used to give the reaction, which was in some instances quite 

 severe. Under the vaccine treatment most of the arthritic cases 

 made noticeable improvement, although it was not to be expected that 

 pathological alterations which had become chronic would be percept- 

 ibly changed or modified. The case of vulvovaginitis was not com- 

 pletely cured despite several injections. The chronic suppuration of 

 the ear was completely cured after the second injection. In a re- 

 cent paper Cowie has briefly reviewed his experience with protein 

 therapy. He finds it most useful in acute and subacute arthritis. 



Boyd has also employed typhoid vaccine, using it in a relatively 

 moderate dosage (50 million) with success in a variety of diseases 

 originating in focal infection, including arthritis. 



In the European literature one finds numerous observations con- 

 cerning the use of nonspecific therapy in arthritis. Typhoid vaccine 

 has been employed less frequently, but milk injections, following the 

 original recommendation of Miiller and Weiss, have been commonly 

 used. (Edelmann, Panczyscyn, etc.) Colloidal metals have also 

 found favor, while Edelmann found that a combined form of therapy 

 using salicylates and milk injections gave results that practically 

 assured success in every case. 



Voigt, Moewes, Voigt and Corinth (iodid-silver colloid), Mukerjee 

 (colloidal sulphur and mercury), Reichmann (colloidal silver), re- 

 port on arthritis treated with the intravenous injection of colloidal 

 metals. 



Zimmer used casein injections both intravenously and intramus- 

 cularly, the dose varying from 1 to 5 c.c. of a 5% solution. He 

 reports on 150 ambulatory cases treated in the Polyclinic and some 

 30 cases treated in private practice. The cases included arthritis de- 

 formans, old rheumatic and traumatic arthritides as well as a num- 

 ber of other origin. His general experience led him to the belief that 

 the most desirable results were obtained when the injections elicited 

 a strong focal reaction with a relatively mild general reaction. 



His cases of subacute arthritis and gonorrheal arthritis were 

 either cured or markedly improved. The immobility incident to the 

 older gonorrheal involvements was not altered. 



