GONORRHEA AND ITS COMPLICATIONS 179 



Sandek found that if he injected salt solution or potassium iodid 

 in from 1 to 5% solution he obtained results that were similar in 

 many respects. There was of course no general systemic reaction 

 when the treatment was carried out in this manner. 



Eisel has continued observations on this method of local injections 

 of physiological salt solution and has reported on 30 cases in which 

 from 10 to 15 c.c. of physiological salt solution were injected between 

 the scrotum and the tunica vaginalis. He states that the pain was 

 lessened very promply and resorption of the inflammatory exudate 

 facilitated in all of the cases of epididymitis so treated. 



Other observers have treated gonorrhea and gonorrheal complica- 

 tions with tuberculin (E. F. Miiller) and with turpentine injections. 

 Piirckhauer, who has tried the latter in acute urethritis, considers such 

 injections of value as adjuvants but not useful in bringing about com- 

 plete recovery from the acute infection, his experience coinciding 

 therefore with that reported with the use of the other related agents. 

 Karo has also used turpentine injections in gonorrheal complications, 

 adding a small amount of eucupin to the dose to lessen the local pain 

 that follows when only turpentine is injected. The largest series 

 treated in this manner is that of Krebs who has treated several hun- 

 dred cases of acute and chronic gonorrhea, with particularly good re- 

 sults in the severer infections. According to his report the course 

 of the acute disease was shortened and complications lessened. In- 

 jections were given every three to five days; after the second injec- 

 tion local treatment was commenced with choleval or with potassium 

 permanganate. While he considers that every case should have local 

 treatment, the general treatment with the turpentine injections had 

 a marked effect in lessening the pain and the secretion after a very 

 short time. 



Reenstierna has made use of a combined specific and nonspecific 

 method of treating the closed gonorrheal complications. He injects 

 not only a specific antigonococcus serum but with it a typhoid vaccine 

 to give the general reaction. With this combined method he claims 

 to have obtained very satisfactory results. 



Franzmeyer has claimed good results in the treatment of acute 

 gonorrhea by using intravenous injections of collargol combined with 

 local treatment. Sommerfeld, who treated 42 men and 10 women 

 ill with acute gonorrhea with collargol intravenously, did not find the 

 results as satisfactory as local therapy. Cohn has reported the treat- 

 ment of 86 men of whom only 13 proved refractory to the nonspecific 

 therapy. Weber, too, has reported that as an adjuvant, the intravenous 

 injection of colloidal metals is of benefit in the treatment of acute 

 gonorrhea. Nuclein has also been used (Boas) while Brown has re- 

 ported on results with normal horse serum as well as diphtheria anti- 

 toxin. He observed that the dose of normal serum which had to be 

 used to secure results was much larger than the diphtheria antitoxin. 



