180 PROTEIN THERAPY 



On the other hand, Riecke has reported that he has never observed 

 a single recovery of an acute gonorrhea following the fever therapy 

 unless local treatment was instituted. From our present knowledge of 

 infections of the mucous membranes it is probable that in acute infec- 

 tions nonspecific therapy has a limited field as an adjuvant to local 

 therapy, while in the gonorrheal complications it finds a much wider 

 and more useful application. 



Buboes. Stark and Odstrcil began the use of milk injections in 

 the treatment of buboes, which, like the other gonorrheal complications, 

 seem to respond very well to this form of therapy. Miiller and Weiss 

 had already noted that certain gonorrheal complications yielded quite 

 readily to the milk injections and Miiller himself has published some 

 25 cases of buboes treated by means of milk injections. With one 

 exception all of these (17 early cases, 7 older ones) were cured with- 

 out surgical incision. Miiller gave injections of milk every 3-4 days 

 using from 5-6 c.c. of milk for the purpose. Usually the local reaction 

 reached its maximum in about 8-9 hours when the greatest pain was 

 noted, after which the part affected became analgesic. In the treat- 

 ment of the old cases an average of 5 injections of milk were made; in 

 the earlier cases 3 or 4 injections sufficed for a complete cure. Tross- 

 arello has also reported on the successful use of milk injections in 

 the treatment of buboes. In 15 cases the injections practically aborted 

 the lesions. 



Schneller treated but two cases with milk injections, but both made 

 complete recoveries without surgical intervention. 



Guszmann has reported that milk injections are followed by ex- 

 cellent results in the treatment of soft chancres, while Antoni using 

 aolan (casein) obtained equally good results in soft chancres and 

 buboes. 



Reichenstein used milk in both buboes and epididymitis. The 

 buboes usually softened rapidly and were then incised; the epidi- 

 dymitis also showed retrogression shortly after the treatment was 

 commenced. No more than three injections were ever necessary. 



Almkvist treated 8 cases of buboes with turpentine with tuberculin 

 and with nuclein injections. The cases all made a rapid and complete 

 recovery. 



Kraus, on the other hand, treated 20 cases of gonorrhea (acute) 

 with milk injections (5 to 8 c.c.) without much apparent benefit. 

 In 7 cases there was no general reaction to the injections; the focal 

 reaction likewise was not marked in any of the cases. Grabisch, 

 using turpentine injections, obtained favorable results in gonorrheal 

 complications such as buboes, cystitis and even pyelitis. 



Karo, who has recently employed "terpichin," a turpentine prepara- 

 tion combined with quinin, has reported on the use of this agent in 

 a very large series of cases. In acute gonorrhea he has used it in 

 combination with the usual local treatment but considers that the 



