182 PROTEIN THERAPY 



extent of the inflammatory changes and their peculiar character this 

 result might be anticipated. In general it may be stated that the 

 findings that hold true for venereal infection in the male hold true in 

 the female, that is, that the acute infection, either cervical, urethral or 

 uterine, is not influenced very much by this form of therapy, that 

 the complications, on the other hand, are remarkably amenable to 

 treatment and at times give exceptionally good results. 



Menzi treated 117 cases with collargol injections, using from 2 

 to 10 c.c. of a 2% solution every two days. He states that of 34 

 cases of urethral gonorrhea, acute and subacute, 23 became nega- 

 tive bacteriologically. Of 7 cases of chronic urethritis, all became 

 negative. Of 24 cervical infection 23 became negative. Two cases 

 of uterine infection were unchanged. Lux, who obtained good re- 

 sults in gonorrheal complications with injections of collargol, obtained 

 negative results in acute infections, and Sommerfeld, too, did not see 

 that in acute cases the treatment was as efficacious as local treatment. 

 Kleemaiin treated 51 patients of this type with injections of 2% 

 collargol; of these 11 were cured, 20 improved, while 20 were not altered 

 clinically. Kleemann is of the impression that the injections shorten 

 the course of the disease and when combined with local treatment are 

 of manifest assistance. Infections of the uterus were also found by 

 him to be refractory. Konteschweller recommends "pyretotherapy," 

 produced by any of the common nonspecific agents, as of value in 

 tubal inflammation. 



Gerstein, working at the clinic at Halle, had used milk injections, 

 but the general effects were at times rather unpleasant so that Kauert 

 first used aolan (casein preparation). With this he treated 16 cases 

 of pyosalpinx. Only one case reacted with a temperature rise and 

 there was practically no leukocytic reaction. In these cases Kauert 

 saw very little clinical change. Not obtaining any results with the 

 aolan Kauert turned to milk injections, but here, too, his results were 

 not successful. This corresponds to the results reported by Chiaudano. 



Trossarello gave parenteral injections of milk in the treat- 

 ment of forty-five cases of gonococcus infection and in fifteen cases 

 of venereal bubo. In the apyretic there is an interval of two or three 

 hours before the chill follows the injection, and this allows ambula- 

 tory treatment as the patients are able to reach home before it. No 

 benefit was apparent in the cases of urethritis, prostatitis, epididymitis 

 and arthritis, but in ovarian and tubal disease marked benefit was 

 realized. All were improved, some after a single injection. His re- 

 sults in these twenty cases of adnexitis surpassed, he says, those ob- 

 tained with specific vaccines or antiserums ; the pain subsided promptly 

 even before any objective improvement was apparent. He injected 

 into the buttocks 5 or 10 c.c. of ordinary milk, at intervals of three 

 or four days, to a total of five injections. The febrile reaction seems 



