190 PROTEIN THERAPY 



the tenesmus and obstipation, but the hemorrhages are apt to per- 

 sist longer. In cases that have diphtheritic membranes Dollken ob- 

 tained good results after repeated injections. 



Of theoretic interest was the fact that in cured cases Dollken was 

 at times still able to cultivate the causative organism (Flexner) from 

 the stool; the agglutination titer of the patient's serum, no matter 

 what the clinical outcome, was not altered by the milk injections, 

 but after specific vaccination was increased. 



Deutero-albumose, tried in several cases by Dollken, was not as 

 satisfactory. Holler, on the other hand, has treated 50 cases of bac- 

 illary dysentery (Kraus and Shiga) with daily injections of deutero- 

 albumose and in this series had only two deaths. 



Liidke treated 14 cases of severe dysentery (12 Shiga and 2 

 Flexner Type) with deutero-albumose injections (3 to 6 injections of 

 from 1-2 c.c. of a 10% solution). Apart from absolute rest in bed, 

 heating pads, and proper diet, there was no other therapy used in 

 these cases. In from 3 to 6 days 12 patients were markedly improved 

 the stools were normal and free from blood or mucus, tenesmus 

 had disappeared and the general condition and appetite returned to 

 normal very rapidly. In two cases, in which an earlier effort with 

 serum therapy had been unavailing, the injections of deutero- 

 albumoses was also without effect. 



Furno treated 5 cases of hemorrhagic dysenteriform colitis, due pos- 

 sibly to mixed infection, with intravenous injections . of proteoses 

 (10 to 12 c.c. of 10% solution). He found that by prompt therapy 

 of this kind the disease is arrested before it reaches the ulcerative 

 stage. 



Reiter found on the other hand that in a small series of cases 

 only one case actually improved. Schelenz, using polyvalent serum 

 and also injections of dysentery vaccine, found that while the course 

 of the fever was not altered very much, the blood disappeared from 

 the stool, the diarrhea decreased and the general condition of the 

 patient improved. 



While specific serum has been used by many clinicians, general 

 opinion seems to confirm the conclusion of Nolf that it is not of great 

 value unless given in huge doses either intramuscularly or intrave- 

 nously and frequently repeated. Pfeiffer used 100 c.c. of polyvalent 

 serum irrespective of the bacteriological finding and gave five to six 

 injections; usually a slight systemic reaction would be observed after 

 the injections. The size of the dose necessary and the fact that it 

 must be given very early if it is to be useful at all leads to the con- 

 clusion that the effect can only be found in the nonspecific stimula- 

 tion by the serum, rather than in any specific antibody content. Schit- 

 tenhelm's results would lead to the same conclusion, v. Scilly and 

 Vertes made use of this feature by injecting their patients with 

 "solusin," a rather toxic agent described elsewhere, from the use of 



