INFECTIOUS DISEASES 197 



injections of 1 c.c. each were given intravenously. These were fol- 

 lowed by chills which usually began one hour after the injection; 

 some headache was also noted. After the first injection there was no 

 temperature rise, nor was it marked after the second injection given 

 the following day, but after the third injection was made 4 days later, 

 there was a reaction of 2 C. The patient was completely cured 

 after the third injection. Lindig treated several other cases with 

 similar results. 



The effect here noted in the temperature curve was reflected in 

 the effect on the leukocytes. After the first injection there was usually 

 only a slight leukocytosis, but with the second or third injection this 

 was much more marked. A well-marked euphoria was observed in 

 every case. 



Kraus in his early work on heterovaccination found that he could 

 bring the febrile course of puerperal infection to a prompt termi- 

 nation by injecting typhoid and colon vaccine intravenously. 



Arweiler in a Dissertation has taken up the use of casein injec- 

 tions in considerable detail and Lindig has reported on the use of 

 such injections as a method of prophylaxis in the puerperium. His re- 

 port covers the results in 61 cases. 



The colloidal metals have been used with some success (Siegel) ; 

 Whitehouse reports success following the intravenous injection of 

 Flavine; Werner has confirmed the earlier reports of Kraus in using 

 typhoid vaccine. Gow uses Witte Peptone. The first dose which 

 may be given intravenously to a septicemic adult is from 8 to 10 

 c.c. The quantity is increased by 2 c.c. every other day or so until 16, 

 18 or 20 c.c. are given at a time. The injection must be made slowly 

 and for that reason Gow employs Nolfs technic using a record 

 syringe and a very fine bore needle with a No. 28 it is impossible 

 to introduce the solution too quickly. In cases of puerperal septicemia 

 the injection of peptone tends to cause an immediate and rapid fall 

 in blood pressure, a rise in the pulse frequency, and if the patient 

 has a leukocytosis, it rapidly induces a high degree of peripheral 

 leukopenia all these phenomena being of very short duration. Of 

 these changes, the easiest to record as a guide is the pulse frequency, 

 and while the injection is in progress the nurse keeps count of the 

 radial pulse, calling out the number each quarter of a minute. Though 

 he is convinced the peptone is a very valuable adjunct to sensitized 

 vaccine, Gow makes no extravagant claim that it always brings a 

 septicemia to an end, and he cautions any who may look for a dramatic 

 and sustained fall of temperature after its use that most times they 

 will be disappointed. 



Bianchi gave parenteral injections of milk in thirty-six obstetric 

 and twenty-one gynecologic cases. He reports that it seemed to pro- 

 mote and accelerate the cure in certain cases and ward off serious 

 disturbances, but when severe puerperal septicemia was under way, 



