INFECTIOUS DISEASES 199 



he saw no unfavorable result from the injections. All recent ob- 

 servers insist that if effects from the serum are to be expected the 

 same must be given within the first three days of the illness. (Rowe, 

 Bennecke, Zingher, Koch, Moog, Reiss and Hertz, etc.) 



Moog as well as several other clinicians used normal serum in doses 

 of 80-100 c.c. In 25 cases 7 responded with a critical drop in the 

 temperature; 13 dropped by lysis; 2 cases died, while in 3 there 

 was no effect. 



Rehde, who treated 89 cases, used normal serum in 14. In both 

 series the results were equally satisfactory. Usually a mild, general 

 reaction was observed following the intravenous injection, that is, 

 the temperature was increased for a short time, a chill noted, as 

 well as some headache. Griesbach in a series of 21 cases observed 

 this reaction repeatedly in his series (8 out of 21 reacted with a 

 chill) and 4 patients went into collapse. Krause, who treated 28 cases 

 of scarlet fever with convalescent serum, also has observed collapse 

 symptoms in a large percentage of the cases (25%). In his series 

 there were, however, only 4 deaths and in 24 the temperature came 

 down promptly after the injections. 



This collapse observed by Griesbach and Krause is, however, quite 

 unusual and Reiss, who has so far treated 221 cases, states that he 

 has never had one case in which collapse and death followed the in- 

 jection. Schultz and Ehrmann have also treated a large number 

 of cases with intravenous serum injections. Ehrmann's cases numbered 

 over 200 and his results were very favorable. He emphasized the im- 

 portance of injecting early in the course of the disease if results are 

 to be expected. 



Schultz' cases numbered 184, of whom 102 were treated with 

 normal serum, 67 with convalescent and 15 with both kinds of serum. 

 He reports very apparent improvement in about 60% of the cases 

 following the injections. 



Prinzing has studied the effect of serum treatment on the com- 

 plications with the following results: Lymphadenitis collci occurred 

 in 15.5% of the injected cases, in 34% of the noninjected; otitis media 

 in 9.3% of the injected, in 10.8% of the noninjected; nephritis in 

 8.2% of the treated and in 18.9% of the nontreated cases. 



Holler has published a series of 32 cases of scarlet fever treated 

 with injections of deutero-albumose (twice daily, 1 c.c. of a 10% 

 solution). There were no deaths in the series and no complications. 

 The course of the disease was in each instance shortened. 



Liidke treated 14 cases of severe scarlet fever with albumose in- 

 jections. The fever very frequently ceased promptly after a single 

 injection, the skin eruption likewise fading and the exfoliation began 

 very promptly. There were no complications and no nephritis was 

 observed. There was no doubt in Liidke's opinion that the injec- 

 tions resulted in a material shortening of the course of the disease. 



