INFECTIOUS DISEASES 205 



typhoid vaccine. Bouygues has employed colloidal metals and 

 Coglievina, who used dispargin a colloidal silver preparation, re- 

 ports that the course of the disease was much less toxic and the mor- 

 tality lower than in untreated cases. He gave on an average about 

 4 injections. Tietze used a 3% solution of collargol (5 c.c.) and 

 noted a lessening of the toxicity. 



The use of silver and antimony colloids has been suggested by 

 Uhlenhuth and Frommes, but the number of cases treated by them has 

 been too small to justify final conclusions. 



Gyozi treated a number of cases with autoserotherapy and found 

 that it seemed of decided benefit particularly in the older cases. 

 Gudzent treated two cases with convalescent serum without apparent 

 success. Raubitschek treated 25 cases with subcutaneous injections of 

 normal horse serum. The mortality was about 6%. v. Zielinski 

 used intravenous injections of the patient's own cerebrospinal fluid. In 

 20 severe cases 5 died. Munk has published a comparative study 

 of the treatment of typhus with normal horse serum, peptone and 

 with nucleohexyl. More recently Schultz, Charlton and Hatziewas- 

 silow have discussed a heterovaccine iriethod which they claim has 

 given good results. They used 2 loops of 48 hours' growth of typhoid 

 organisms (killed at 60 C.) which were mixed with 5 c.c. of the pa- 

 tients' serum. This sensitized vaccine was then injected. A rather 

 sharp reaction followed the injection but the clinical results seemed 

 very satisfactory. In the series of 5 cases all recovered. 



Perhaps a method that is equally successful is that described by 

 Danielopolu in his recent treatise on Typhus Fever. The author uses 

 daily injections of hypotonic salt solution (0.065) which are given 

 intravenously. In his untreated series the mortality was very great, 

 in the treated fully 90% recovered. 



VINCENT'S ANGINA 



Capitan treated 200 cases of Vincent's angina with intramuscular 

 injections of colloidal arsenic (6 c.c.). The cure was complete in 

 from 24 to 48 hours. No local treatment was necessary. Stuhl re- 

 ports a similar nonspecific method of therapy in using tuberculin 

 in the treatment of Vincent's angina. While he treated but a small 

 number of cases the results were quite striking. 



