208 PROTEIN THERAPY 



sive results). Inasmuch as milk injections seem to be very active 

 in influencing the liver (increase in thrombokinase, fibrinogen, shed- 

 ding of glycogen, etc.) Dollken determined to use milk therapy in 

 place of the serum either normal or convalescent. The styptic ef- 

 fect of the milk injections might be expected to become manifest in 

 the course of the disease. In one very severe and quite hopeless case 

 he injected 3 c.c. of milk; the bleeding from the intestine ceased after 

 five hours but the patient nevertheless died. In other less toxic cases 

 Dollken observed a decided effect on the pigmentation of the skin. 

 In several cases injected with albumoses and with milk there was 

 practically a clearing of the jaundice in from 48 to 72 hours. A mild 

 grade of jaundice persisted, however, in these cases despite further 

 injections. The effect on the albuminuria was also quite marked, a 

 single injection being sufficient to completely clear up the urinary 

 findings. Dollken was not able to follow his cases for any length of 

 time so that it is not possible to draw any positive conclusions from 

 the work. There seems little doubt that nonspecific injections, par- 

 ticularly of milk, are able to effect the liver metabolism considerably 

 and may so alter disease processes which have their principal effect 

 in the liver parenchyma. Inada and his associates have also studied 

 the effect, of the injection of serum on the course of Weil's disease. 



MALARIA 



Activation. The provocative effect of 'nonspecific injections has 

 been made use of not only in activating latent gonococci, but also in 

 cases of suspected malaria. 



Thaller noticed that after milk injections in cases that were sus- 

 pected of malarial infection the plasmodia could be demonstrated after 

 the reaction in a certain number of cases. In thirty cases so in- 

 jected 13 responded with the usual milk fever, in 12 a malarial type 

 of fever was activated, in 5 there was no effect. Habetin used sub- 

 cutaneous injections of nucleic acid to mobilize the plasmodia and 

 Heese found that after nonspecific injections plasmodia could be dem- 

 onstrated and paroxysms commenced one week after the injection. 

 Schlesinger observed that malaria plasmodia were mobilized after 

 typhoid inoculation; Freund also observed the activation of an old 

 malaria after an intravenous typhoid injection, while Zupnik, 

 v. Miiller and Leiner report an interesting case of a double infection 

 with typhoid and malaria in which the malarial paroxysms resulted 

 in a typical nonspecific defervescence of the typhoid fever. 



Therapy. Silvestri would support the specific treatment of 

 malaria with injections of foreign protein, serum, adrenalin, strychnin, 

 etc., claiming that the combined treatment is better than when quinin 

 is used alone. It is very possible that such measures may be useful 



