214 PROTEIN THERAPY 



particularly milk, and have used it in the treatment of anemia. Thus 

 Miiller describes its use in the treatment of secondary anemia. 



In pernicious anemia Grote obtained fair results with the injection 

 of milk, one case increasing in blood count over 900,000 in a period 

 of 8 days. As a rule he obtained little febrile reaction after the in- 

 jections, contrary to the experiences of Schmidt in this class of cases. 

 Miiller claims to have had favorable results in bringing about re- 

 missions after milk injections (aolan) which increased the blood 

 count and brought about an increased feeling of well being on the 

 part of the patient. 



Hollaender as well as Fischer reports some success with collargol 

 injections. The effect is never a permanent one. 



HEMORRHAGIC DIATHESIS 



Dollken has devoted considerable attention to the effect of non- 

 specific therapy on blood diseases. That serum injections of various 

 kinds have been found useful, indeed have in many instances been 

 our only resource in the hemorrhagic diseases is, of course, well known 

 and the literature is readily accessible so that it will not be nec- 

 essary to enter into a discussion of it at this time. (P. Emile Weil, 

 Chalier, Kurtz, Lewisohn, Berghausen, Know, Peterson.) * 



Dollken assumes that the bleeding in purpura is largely due to 

 two factors an increased fragility of the blood vessels and the altera- 

 tion in the blood coagulability whereby it does not clot while in con- 

 tact with the tissues. Perhaps when once shed the blood may show 

 some delay in coagulation, but Klinger and others have denied this. 

 Dollken considers the alteration in the platelet count as a symptom 

 rather than a causative factor because in cases that have been long 

 cured he has observed that the diminution in the platelet count may 

 persist. 



The leukocytosis of spontaneous fever, following vaccine injec- 

 tion, and following the intravenous injection of deutero-albumose has 

 practically no effect on the outcome or course of a purpura, the stimu- 

 lation of the spleen and bone marrow that is involved seems insuffi- 

 cient to alter the disease process. (See also the paper of Radovici and 

 lagnov.) 



On the other hand, milk injections seem to have a particular effect 

 on the blood vessels of smaller caliber and on the coagulation 



*The effects of the serum injection are possibly due to the alterations in 

 the amount of fibrinogen and thrombokinase that follow nonspecific injections 

 of various kinds. Moll observed this increase and von den Velden, and Lowy 

 have confirmed it for gelatin, serum, peptones and parenterally injected proteins 

 in general. Moderakowski and Orator also studied the effect on fibrinogen and 

 confirmed the previous workers. Wohlgemut has in a very recent paper demon- 

 strated that the increase in fibrinogen probably results from liver stimulation, 

 but that the thrombokinase arises elsewhere. 



