218 PROTEIN THERAPY 



the maximum therapeutic effect was observed in about 6 hours 

 after the injection. 



Cadbury has described the results obtained with typhoid vac- 

 cines in a group of cases with neuritic pains due to a variety of 

 causes. These included one carcinoma of the breast, in which there 

 was temporary relief from pain; four gunshot injuries, all of which 

 were cured; one fibroid phthisis which was relieved, 1 tic douloureux 

 which was improved for 6 months, etc. 



Boyd also reports the successful treatment of neuritis with mod- 

 erate doses of typhoid vaccine intravenously. 



Following nonspecific injections in neuritides a distinct focal re- 

 action may become manifest. There may be a transient increase in 

 the pain and other manifestations of the lesion that reaches its max- 

 imum in from 4-8 hours, depending on the method used to elicit the 

 reaction, followed by an analgesia which in some instances may be 

 transient, in others permanent in character. 



Wishura using "vaccinurin" found that neither the focal nor the 

 general reactions were very severe. In severe degenerative inflam- 

 mation of nerve trunks as well as in the more common joint neuroses 

 the injections were very successful. 



EAR AFFECTIONS 



Rauch reports the results of milk injections (5 c.c) in 41 cases 

 of acute middle ear infections. According to his series the results 

 were very favorable, only three of the cases requiring operative in- 

 terference. Gomperz, on the other hand, obtained no satisfactory 

 results and Hirsch, who used turpentine injections in cases of furuncu- 

 losis and eczema of the meatus, as well as in acute and chronic sup- 

 purative conditions of the ear, obtained entirely negative results. 



The first report on the subject was that of Alexander, who has 

 described his results in ear diseases and sinus infections ; later Lawner 

 reported some cases of middle ear disease treated with milk injections 

 with excellent results. 



MALIGNANT NEOPLASMS 



A number of procedures and "cures" for both carcinoma and 

 sarcoma have been advocated during the course of more recent years 

 which have had as the basis of their mechanism the alterations which 

 we now recognize as due to nonspecific stimulation. I need but re- 

 call the treatment of cancer with trypsin and amylopsin injections 

 by Beard and the treatment of sarcoma by the injection of Coley's 

 fluid, a bacterial autolysate; or the use of tumor autolysates or serum 

 (Lewin) for purposes of immunization. These and all other methods 

 that provoke a similar systemic response are followed by one of 

 two reactions on the part of the patient. 



