226 PROTEIN THERAPY 



cases as controls. The treatment consisted of injections of one-half 

 gram nuclein in 10% solution. The average duration of life of the 

 treated cases was 15 months, of the untreated 7 months. Later he 

 treated a further series, this time with larger doses from % to 3 

 gm. in 10% solution every 3 to 5 days. Of these ten were treated, 

 ten untreated. The treated cases gave 5 remissions (three becoming 

 progressively active again). In the ten control cases there was but 

 one remission, that following a long continued septic condition. 



Donath treated 21 cases with injections every 5 or 7 days, each 

 injection resulting in a febrile reaction that lasted for one or two 

 days. On an average 8 injections were given the patients; the leu- 

 kocytic reaction was quite marked, up to 61,000 in one case. Of 

 these cases 70% showed definite evidence of improvement in 47%' 

 the improvement was so great that they became self-supporting. 

 He noted that the tremor decreased, excitement diminished, there was 

 an improvement in memory and in mental agility. The longest period 

 of remission initiated by the therapy was 3 years. 



In a second series of 15, 9 showed definite improvement, of whom 

 3 were able to again become self-supporting. 



Hauber gave a combined antiluetic and nonspecific treatment to 

 36 patients. Of these 13 improved, but 23 showed no evidence of 

 therapeutic effect. 



Szedlak treated 25 patients simply with the nucleic acid and an 

 equal number with nucleic acid and mercury with the following re- 

 sults: 



Nuc. alone. Nuc. and Hg. 



Marked improvement 8% 40% 



Slight improvement 24% 24% 



No improvement 31% 16% 



Interrupted treatment 4% 4% 



Died 33% 16% 



In a more recent paper V. Jauregg reported the treatment of 33 

 cases with staphylococcus vaccine in lieu of tuberculin formerly used. 

 In this series 61% improved, 10 of the patients being restored to 

 almost normal health, v. Economo reported similar results. Schacherl 

 treated 38 cases of general paralysis (ambulatory) with a combined 

 course of tuberculin and mercury. Of these 13 continued the course 

 to completion. Seven of these were much improved, 5 of them were 

 again enabled to earn their living. One developed a phlegmon after a 

 severe eczema; this patient became lucid and was permanently cured. 



Of course these favorable results have not been allowed to stand 

 unchallenged. Hiissels, Lepine, Jolowicz, Plange and Hoppe failed to 

 find any therapeutic benefit from the use of tuberculin or the nucleins 

 when injected. Lowenstein and Kleinberger have indeed claimed that 

 the injections have done actual harm. Bouman, who used tuberculin, 



