TREATMENT OF GENERAL PARALYSIS, TABES, ETC. 227 



nucleinate and salvarsan, got very little results with any of them, 

 the effect obtained being at the most transient. 



Brown and Ross have discussed this treatment of mental dis- 

 eases by the production of leukocytosis, treating 9 cases by means of 

 nuclein injections. There was not much mental improvement despite 

 the fact that a leukocytosis of from 17,000 to 20,000 was obtained in 

 many cases. 



Bruce has reported on the use of turpentine and sodium cinnamate, 

 and collargol has also been tried by Vergueira in a dose of from 5 

 to 10 c.c. of a 1% solution. 



Friedlander has used intravenous typhoid injections; Plaut tried 

 out the effect of injections of streptococcus and of staphylococcus vac- 

 cines without apparent results; the leukocytic response was of low 

 grade. Recently v. Jauregg has even suggested the infection of the 

 patient with malaria plasmodia to keep up a febrile reaction at 

 definite intervals. Weichbrodt and Jahnel report on a number of cases 

 so treated and Miihlens, Weygandt, and Kirschbaum have recently 

 reported on a series of 33 cases treated by infecting the patients 

 with the spirillum of Obermeier and malaria plasmodia. Of their series 

 12 were of such recent date that the end result could not be properly 

 judged. Of the remaining 21, 4 cases died (not directly from the 

 infection) , while 12 were markedly improved, with remissions persist- 

 ing for a considerable time. The papers by Steiner and Pagniez are 

 also of interest in the same connection. A review of the entire sub- 

 ject will be found in articles by Enge and by Raecke. 



We are perhaps justified in assuming that the work of the Vienna 

 school in this particular field may offer some advance in our methods 

 of therapy which, at best, are none too satisfactory. That intercur- 

 rent infections affect the degenerative process or at least the rate 

 of destruction is very likely from what we know of their effect on 

 other pathological conditions, and there is no reason why the various 

 nonspecific procedures suggested may not at times be followed by 

 some clinical improvement. It seems possible that in a combined 

 ergotropic and etiotropic method some dependable results may yet 

 be achieved. 



TABES 



Dollken has treated some cases of tabes, but a larger series has 

 been reported by Schacherl. Schacherl used a combined specific and 

 nonspecific method of therapy, beginning with 0.001 gr. of tuberculin 

 and then giving 0.1 gm. of salicylate of mercury with each third dose 

 of tuberculin. He observed that early in the course of treatment, 

 i.e., when the patient had considerable reaction from the tuberculin, the 

 effect of the mercury was also much more in evidence, salivation being 

 noted much more frequently. 



With this method of treatment the results in 76 cases, with one 



