SKIN DISEASES 233 



injections and resorcin, using resorcin as a local application and giving 

 turpentine injections every two days. He commenced with a dose of 

 0.25 c.c. of the 20% turpentine in olive oil, advanced to 0.5 c.c., 

 then followed to 0.75 and 1 c.c. doses during the course of the treat- 

 ment. He found the treatment of great value in the deep indura- 

 tive forms; in these, injections of trichophytin were also found use- 

 ful. The cases were cured as a rule in about 3 weeks ; the fungus dis- 

 appeared from the lesions generally during the course of the first 

 week. In four cases (of 30) there was some temperature reaction 

 after the injections, one of these cases reaching 39.6 C., but Fischl 

 does not consider the clinical effect in any way depending on the 

 degree of temperature rise. 



Miiller used turpentine diluted with paraffin oil in the treatment 

 of trichophyton infections with satisfactory results. He used no local 

 treatment. There was no evidence of kidney irritation following the 

 injections. Grabisch began the use of turpentine injections in the 

 same condition and gradually extended his use of the injections to 

 acute eczema, dermatitis, drug eruptions, gonorrheal complications, 

 urticaria, strophulus, erythema multiforme, dermatitis herpetiformis, 

 furunculosis, pyodermia, etc. 



Ruete, on the other hand, found that turpentine injections were 

 not followed by particularly favorable results in trichophyton infection 

 although he obtained very satisfactory results in furunculosis. 

 Schmidt (H. E.) reached the same conclusion. Using Klingmueller's 

 method he treated 8 superficial cases and 6 with deep seated lesions. 

 In the latter cases the results were far better than in the superficial 

 ones, but even these were not cured. In 5 cases of furunculosis his 

 results were very satisfactory. Schedler's results were more satis- 

 factory. 



Sachs recommends intravenous injections of hexamethylenamin 

 (40% sol.) in the treatment of deep trichophyton infection, with large 

 nodules. As a first dose 6 gm. (15 cm. of fluid) are injected; on the 

 second or third day after the first injection the dose is increased to 

 8 gm. In one case 8 gm. were given as a first dose, which was in- 

 creased to 12 and 14 gm. The number of injections required and 

 the exact quantities of hexamethylenamin that will be needed cannot 

 be definitely stated in advance. Of ten patients so treated, one was 

 cured after a single injection of 4 gm., another after three injections 

 of 4, 6 and 8 gm., respectively, in ten days; another patient received 

 four injections (once 6 gm. and three times 8 gm.), and was cured 

 in fourteen days. 



Singermann found turpentine injections (10%) useful in furun- 

 culosis and in eczema, and Becker reports success in the treatment of 

 various dermatoses. 



Reese used milk injections (aolan) in 175 cases of trichophyton 

 infection. He found that the cases were as a rule cured in about three 



