238 PROTEIN THERAPY 



several cases of ophthalmoblennorrhea improved rapidly. In tuber- 

 culous iridocylitis the improvement was not marked. 



Both Igersheimer and Kraupa obtained remarkable results in iritis 

 and found that in gonorrheal disease the results were usually very 

 satisfactory both in adults and in children. 



Jacovides treated about 221 cases of ocular disease with nonspecific 

 therapy. In 150 cases of ulcer of the cornea 140 were cured after 2 

 to 3 injections. 



Jickeli, using milk, treated ophthalmoblennorrhea, iritis, choroiditis 

 and ulcers of the cornea with satisfactory results; milk therapy has 

 found many partisans among French and Latin clinicians, and the 

 reports of Carreras, Darier, Dimmer, Miiller, Domec, Mansilla, 

 Arganaraz, Gaupillat, Guibert are available, while Titus and Nolf 

 have used intravenous injections of peptone. Nolf has paid particular 

 attention to this form of therapy in ocular complications following 

 typhus, typhoid and septicemia. Guibert obtained his most satis- 

 factory results in scrofulous diseases. Gaupillat obtained very satis- 

 factory results in hypopyon keratitis and in bulbous infection. He 

 used milk injections for subconjunctival injection in one case. 



Darier, one of the earliest advocates of paraspecific therapy, used 

 milk injections together with oral administration of serum, which, as 

 Cumston has recently mentioned, is so frequently used as a routine 

 by French clinicians. Darier's results in infectious ulcers of the 

 cornea and in iritis traumatic as well as postoperative were very 

 satisfactory. In keratitis parenchymatosa and in trachoma he does 

 not consider his results conclusive. 



Darier has been indefatigable in his advocacy of the oral ad- 

 ministration of serum, claiming that with little reaction on the part 

 of the patient the polyvalent serum exerts a systemic stimulation com- 

 parable to the effect of milk, peptone or colloidal metals injected into 

 the patient. According to Darier some diseases are affected more by 

 one than the other of these agents so that some clinical experience 

 must be gained before it is possible to use them with greatest success. 



Quite a number of observers have reported on the use of milk in- 

 jections in the treatment of ophthalmoblennorrhea, among them Jickeli, 

 Nassbaum, v. Liebermann, Purtcher, Mtiller, Holler, Sommer, Honig 

 and Bachsteg, all but the latter noting marked benefit following the 

 milk injections. Liebermann undertook the treatment of a large series 

 of cases of gonorrheal ophthalmia in adults with milk injections, but 

 at the same time did not fail to continue the usual local treatment. 

 He found that the effect of the injections on the symptoms was as 

 follows: The secretion usually ceased after the first or the second 

 injection and only rarely recommenced. The demonstration of the 

 organism in the exudate became more and more difficult as the effect 

 on the amount of secretion became apparent; only in exceptional 

 cases did he obtain a positive bacterial finding after the secretion had 



