SMALL-POX AND VACCINIA 53 



four hours after inoculation of its cornea with vaccine lymph, and the 

 juice of this rabbit's kidneys be used to inoculate other rabbits' 

 corneae, the latter exhibit the same changes as if inoculated with 

 vaccine lymph. 



The foregoing account embodies some of the observations and 

 views of those who believe that Guarnieri's bodies and their 

 derivatives are protozoa. It is natural that others have taken the 

 contrary view, or views as it may be more correctly stated, since 

 the critics differ very widely. Thus Ferroni and Massari said that 

 Guarnieri's bodies were derivatives of the nuclei of leucocytes and 

 epithelial cells, and that they could be produced by injury of the 

 cornea. This has been found to be incorrect. Salmon and Borrel 

 regarded them as derived from leucocytes, and that similar bodies 

 occur in sheep-pox. The latter part of their contention has been 

 confirmed, but not the former. One of the best and most careful 

 pieces of work on the negative side is that of Hiickel j 1 but to those 

 who have carefully studied Guarnieri's bodies it is evident that he 

 has confused leucocytes and other structures with them. Copeman 

 and Mann- do not commit themselves ; they recognise Guarnieri's 

 bodies in various vaccine lesions of the calf, and observe that 

 ' Clarke rightly points out that many cells appear similar to those 

 found in cancer.' 



More recently Prowazek 3 has advanced the view that Guarnieri's 

 bodies, though specific, are not the virus of the disease, but some 

 part (nucleolus or chromidium) of the host-cell that escapes from 

 the nucleus, invests the true parasites, and grows with them. 

 This view has been framed to account for the fact, referred to above, 

 that the virus will pass a fine filter. It is^to my mind more probable 

 that the whole vaccine-body is a parasite in the chromidial con- 

 dition, and that the disintegration of its body does not necessarily 



1 A. Hiickel, ' Vaccine-bodies,' Beitriige znr Path. Anat., xxv., 1898. Supple- 

 mentary part. 



2 Monckton Copeman and Mann, Twenty-eighth Annual Report of the Local 

 Government Board, 1898-1899, Appendix C. 



3 Prowazek, ' Untersuch. ueb. Vaccinekorp,' Arbeit, aus der Kaiserl., xxii., 

 1905, p. 535- 



