90 PROTOZOA AND DISEASE 



most important features, which I will place before the reader as 

 objectively as possible, putting out of mind all definitions of ' cancer '; 

 at the end of the description I will give my interpretation of the 

 phenomena before us. Examining first at many points the peri- 

 pheral part of the main growth and several of the secondary nodules, 

 I found that in all a gradual continuity of the connective-tissue cells 

 with those of the tumour could be clearly traced, as is shown in 

 Fig. ai. 1 



This fact is of the very greatest importance, and will bear being 

 restated : The cells that form the basis of this alveolar sarcoma are granula- 

 tion-tissue cells in other words, this alveolar sarcoma is a granuloma. 



Inside the marginal zone the structure of the tumour was similar 

 throughout, and an average area examined under a higher power is 

 shown in Fig. 32. 



This is drawn from a specimen made twelve years ago, and 

 stained with Ehrlich's haematoxylin and eosin, and the colours are 

 still quite definite, almost as much so as when the specimen was 

 first made. The most striking feature is the presence of intranuclear 

 bodies, which recall the nucleoli of nerve ganglion cells or of ova. By 

 tracing the derivation of the tumour-cells, the latter, as has been 

 already pointed out, are seen to be granulation-tissue cells. Are the 

 intranuclear bodies nucleoli ? A wider study of this sarcoma is 

 necessary before this question can be answered. Here I will only 

 refer to the description of Fig. 32, where reference to other bodies 

 is also made. Other sections were stained with Biondi's reagent, 

 and from one of such in 1895 I made a coloured drawing, which I 

 have before me. The peripheral processes of the intranuclear bodies 

 were seen in the Biondi-stained sections better than in sections 

 stained in other ways. They are stained a brownish-orange colour, 

 and many of them are seen to possess knobbed ' tentacles ' like those 

 of suctorians. In the hsematoxylin preparations the ends of these 



1 If any illustration in this book e.g., Figs. 31, 32, etc. is described as a camera 

 drawing, I shall be pleased to arrange to show the original specimen to anyone 

 who may wish to see it, but I cannot again send specimens by post, having lost 

 several in this way. 



