AN ALVEOLAR SARCOMA 95 



nuclear bodies described above as occurring in variola e.g., see 

 p. 50, Fig. 13 ; 7. 



To continue the objective study of this tumour, I will refer to 

 reproductions 1 of various types of cells and bodies that are to be 

 seen in the sections of it, and are represented in Fig. 36. It will 

 be best to consider average examples of cell-forms chosen^ from 

 many hundreds of carefully studied areas in sections of this sarcoma, 

 such examples being carefully drawn from the actual object. The 

 points for study may be taken in some definite order as follows : 



i. The Fate of the Intranuclear Bodies. In. some cases the intra- 

 nuclear body appears to be attached by a pedicle to the nuclear 

 membrane, as in Fig. 36 ; /. It has been observed above in con- 

 nection with Fig. 34 that, previous to its escape from the nucleus, 

 the body appears to become attached to the nuclear membrane in 

 another manner ; this is shown also in Fig. 36 ; 2, where the nuclear 

 membrane is drawn inwards. In many instances bodies in every 

 way similar to those in the nucleus are seen to lie in the cytoplasm 

 or in the spaces between the tumour cells ; and in some cases, as in 

 Fig. 36 ; J, the body remains attached to the nucleus. In Fig. 32 ; 2 

 two such bodies have the appearance of being fused together ; they 

 are also assuming a clearer aspect, and spreading outwards at their 



1 Some of these have been already published in the Cent, fiir Bakt., May 10, 

 1895, w ^h my article on 'The Biology of an Alveolar Sarcoma' ; some were made 

 at the same time, but not published ; the remainder have been carefully drawn in 

 moments of leisure since the year 1895. In the description of Fig. 36, for sim- 

 plicity's sake, the author's interpretations of the various bodies is given, anticipating 

 the conclusions to follow. 



with basiphile chromatin in process of formation around oxyphile masses ; 10, same 

 as 9 below, and a spindle with ordinary chromatin above ; II, parasite with chro- 

 matin in foci somewhat resembling leucocytes ; 12, parasite similar to 9, but with 

 basiphile chromatin in a network enclosing three oxyphile bodies : such stages 

 in the parasites simulate nuclei of somatic cells; 13, a parasite with radial 

 monilifonn chromatin ; 14, parasite with chromatin in a form resembling an 

 irregular spireme a 'giant mitosis '; 15, a parasite showing below the formation 

 of a ' gemmule ' by chromatin streaming into a localized area, and elsewhere 

 stages in gemmule-formation ; 16, a parasite with multiple gemmule - formation 

 at the surface : also a free gemmule provided with tentacles, and four leucocytes ; 

 17, a parasite with central gemmule formation ; 18, a parasite from which gem- 

 mules have been formed, and all but three have escaped; 19, a reticulum from 

 which all the gemmules have escaped. 



