AN ALVEOLAR SARCOMA 97 



described (Fig. 36 ; 4\ In others the chromatin consists of a single 

 central mass, or several such. Spindles of the ordinary characters 

 are present in some of these cells, and simple binary division of the 

 chromatin mass, with or without formation of definite chromosomes, 

 may occur in them, as in similar cells of other sarcomas ; ^butin this 

 tumour the result of this form of nuclear activity was limited to the 

 formation of the small roundish bodies shown in Fig. 36 ; 7 and 8. 

 The cells (Fig. 36 ; 9 to 18) are described with the plate, and need 

 not be further discussed here. A few words as to the formation of 

 the small rounded bodies, which have already been considered as 

 they arise from the flowing of chromatin matter along the spindle. 

 In Fig. 36 ; 15, is a cell containing two chromatin masses. From 

 the lower one of these a stream of chromatin particles is passing 

 into a limited area of the cytoplasm ; and near the same chromatin 

 mass are two rounded bodies. Above is a second chromatin mass 

 adjoining a round body with slender peripheral rays. From long 

 and close study of the cells of this tumour I have no doubt that 

 such round bodies arise from the mixture of a chromatic and a non- 

 chromatic substance, and that they are minute cells 1 which may be 

 termed ' gemmules.' The peripheral rays probably have the same 

 significance as the achromatic strands of ' linin ' that make the 

 spindle in cell-division. Another mode of gemmule-formation is 

 that shown in Fig. 36 ; 16. The lobed chromatin body in this case 

 was translucent, probably from the chromatin being very finely 

 divided ; the linin system pervades the whole of the cytoplasm, 

 making lines which converge at the points where gemmules are 

 being formed. Near this cell are a free gemmule and four leuco- 

 cytes ; the latter are quite easily distinguishable, and appear not to 

 have been phagocytic as regards the gemmules, none of -which are 

 seen inside them. Other modes of gemmule-formation are seen in 

 Fig. 36. 



1 In anticipation of the conclusions stated below I may here mention that I 

 regard these ' gemmules ' as homologous with the endogenous bodies described in 

 Chapter VIII. and shown in Fig. 18, as they occurred in living jsyphilitic cells 

 /./:., they are the equivalents of Virchow's 'cells of endogenous origin,' and of 

 the 'bird's-eye- bodies of cancer. See section on Syphilis, p. 60. 



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