THE STRUCTURE OF A ROUND-CELLED SARCOMA 109 



intranuclear body of considerable dimensions. These intranuclear 

 bodies stained with the acid stain in mixed stains, such as Biondi, 

 and haematoxylin and eosin, the cytoplasms of the tumour-cells being 

 of but slight consistence and small in amount. The connective 

 tissue (Fig. 42 ; 5) of the tumour had its fibres slightly swollen 

 (mucoid degeneration), but its cells were easily recognisable, and 

 they could be traced in unbroken gradation to the tumour-cells just 

 described. Thus, as in the case of the alveolar sarcoma of the 

 breast described in Chapter XII., the cells forming the basis of this 

 tumour of the testis are connective-tissue or granulation-tissue cells. 

 Amongst these elements were others which could not be traced as 

 having arisen from the normal tissues. Such were dense intracellular 

 bodies (Fig. 42 ; /), or similar bodies free, as at 2, and, among other 

 forms, large cells in mitosis, such as 3. In some of these cells the 

 chromatin was massed in an equatorial phase, with a single spindle 

 and without visible division into chromosomes, but more were irregular 

 or multiple mitoses, and many other forms indicating cell-division, as 

 shown in Figs. 42 and 44, were present. A group of cell-forms 

 sketched in one of the areas, such as that marked 2 in Fig. 41, are 

 shown in Fig. 43. Remembering that this drawing was made in 

 1893, it is interesting to note, among other features, the character of 

 the nucleus of the cell-inclusion at 2. Compared with the nucleus 

 of the ookinet of the Spirochczta Ziemanni (see Fig. 4, p. 21) a close 

 similarity will be noted. The dense encapsuled body, J, with but 

 a trace of the outline of the nucleus remaining, is characteristic 

 of certain encapsuled protozoa in a chromidial condition. 



Let us now attempt to reconstruct the cell-life of this tumour 

 i.e., the sources of the various kinds of cells it contains, or what is 

 sometimes called the histogenesis of the tumour. 



Starting from one of th^ arterioles that are contained in one of 

 the strands of connective tissue such as 4 in Fig. 41, we trace the 

 connective-tissue cells as their nuclei enlarge and the intranuclear 

 bodies appear; then we search minutely for stages of mitosis to 

 connect these swollen connective-tissue cells with the groups such as 

 2 in Fig. 41, but we find no evidence of such stages. On the 



