ii6 PROTOZOA AND DISEASE 



are abundant. Free bodies, of which I have been unable to find the 

 homologues in foetal connective tissue, characterized by a proto- 

 plasm similar to that of well-known sporozoa that is to say, of 

 peculiar density and correspondingly high refractive power occur in 

 great numbers in every part of the growth. In many places they 

 are seen to be dividing by regular mitosis, but for the most part 

 presenting irregular mitotic figures and giving evidence of intense 

 vitality by their simultaneous subdivision into a great number of 

 daughter cells. Some of these bodies are of great size (30 to 40 /*), 

 with several central chromatin foci, generally hollow rhomboids 

 with peripheral offshoots, and at the surface clusters of small 

 rounded 2 to 6 /* particles, some with, some without, nuclei.' The 

 larger bodies referred to in the foregoing paragraph resembled in 

 optical appearance and staining reactions as well as in their wide 

 range of nuclear forms bodies that I described in 1892 as protozoa 

 in a squamous epithelioma of the septum of the nose of a man. 



On re-examining the sections of this myxosarcoma, in spite of much 

 fading (they are Biondi- stained), I can still recognise the structures 

 referred to in the above passage. With regard to the bodies that 

 are undoubtedly intracelluJar, these exactly resemble those that I 

 have figured and described in another sarcoma, and are reproduced in 

 Fig. 45. There is no possibility of mistaking for leucocytes or other 

 wandering cells these highly refracting, coarsely reticulated cell- 

 inclusions, whether nucleated or not ; and in a tissue of loose texture, 

 such as a myxosarcoma, there can be no question of invaginated 

 cells simulating cell-inclusions. 



Quite recently 1 I have again referred to this case of sarcoma as 

 follows : 



'Twelve years ago 2 a paper of mine on the cell-forms in a 

 sarcoma was published ; incidentally it dealt with the work of Klebs 

 and von Hansemann. Unfortunately, no illustrations were pub- 

 lished with this paper, but, having kept them, I reproduce three in 

 this place (Fig. 46). Such cells may be " gametoid," but there is no 



1 Brit. Med. Journ., June 2, 1906. 



2 Transactions of the Pathological Society, 1894. 



