VOL. LXXXVI.] PHILOSOPHICAL TRANSACTIONS. 67 



ginning to the end of the experiment, in consequence of the red globules being 

 dissolved; it had a very offensive smell, but never deposited any white sediment; 

 the coagulating lymph dissolving from putrefaction. As it is evident, from the result 

 of the last experiment, that the coagulum remaining so long undissolved in the 2d 

 experiment depended on its being mixed with the urine, I was desirous of knowing 

 whether it was the urine incorporated with the coagulum, .or that which sur- 

 rounded it, which produced this effect. To determine this point I instituted the 

 following experiment. 



Exper. 4. 4 oz. of blood were drawn from the arm into a cup, and allowed to 

 coagulate ; 4 oz. more were drawn into a separate cup. From each of these equal 

 portions of coagulum, at the end of 3 hours, 1 oz. of serum was separated, and 

 poured off. To one of them fresh urine was added: to the other common water. 

 The urine and water were changed night and morning. The water was tinged of 

 a bright red colour throughout the whole experiment, and deposited no sediment. 

 On the 8th day the coagulum was rather looser in its texture. On the 13th day it 

 began to break, and by the 20th day it was nearly dissolved. The progress cor- 

 responding with that of the coagulum in experiment 3. The urine the 2d day of 

 the experiment was clear, but the bottom of the basin was covered with red glo- 

 bules, undissolved. On the 5th day, the urine poured off was tinged of a bright 

 red colour; similar to the water taken from the other coagulum; and after standing 

 some hours a white sediment was deposited. On the 13th day it was looser in tex- 

 ture, and more dissolved than the coagulum in the water. It continued to tinge 

 the urine of a bright red colour, and what was poured off deposited a white sedi- 

 ment in greater quantity. On the 18th, the coagulum was nearly dissolved; so 

 that the coagulum immersed in the urine dissolved two days sooner than that in the 

 water. 



From this experiment we find, that it was the urine incorporated with the 

 coagulum in experiment 2, that prevented the red globules from dissolving, and 

 preserved the coagulum for so long a time, since these effects were not produced 

 by urine while simply surrounding the coagulum. If we compare experiment 2, 

 with the result of the case, they agree so entirely, that it leaves no doubt of the 

 process carried on in the bladder being similar to that which took place out of the 

 body. The patient was unable to make water for 24 days, though the passages 

 readily admitted, during the whole of that time, an uncommonly large instrument, 

 which could not have been the case had there been any obstruction in them ; for 6 

 days more he voided it with difficulty, but afterwards made water very well. The 

 coagulum out of the body was reduced in 25 days to the size of a cherry, and in 4 

 days more it was completely dissolved. The patient's urine became darker, from 

 the red globules mixing with it in 9 days. In the experiment this took place in 5 

 days. The white sediment was first observed, in both instances, about the 12th 

 day ; it continued to be deposited till the patient got well, and to the end of the 

 experiment. 



k 2 



