73 



centric bodies of Hassall; no atrophic changes are yet noticeable. 

 A very prominent feature of sections of this gland is the presence 

 of very numeroiis plasma mast cells with large, eccentrically situated 

 vesicular nuclei and many coarse basophilic granules. The gland 

 tissue proper does not contain any extensive areas of extravasated 

 blood. However, the capsule and the periglandular loose areolar 

 tissue show considerable blood extravasation. Only very few bacilli 

 can be found in these sections. The renal tissue shows a moderate 

 degree of cloudy swelling. Many of its tubules are more or less 

 completely filled with a granular material, some of them containing 

 hvaline casts. A moderate number of glomerular vessels show 

 h5'aline (fibrin) thrombi. Nowhere is this thrombosis very exten- 

 sive or at all complete; it affects only a minor part of the vessels 

 of one glomerulus. The renal vessels in general are very much 

 congested, and a very few small areas of blood extravasation are 

 found. The few bacilli which are visible are found in connective 

 tissue — lymph clefts or in the capsular space of a glomerulus, but 

 not inside of blood vessels. The liver shows a few small inter- 

 lobular inflammatory foci and a moderate degree of fatty degenera- 

 tion of the parench3^ma cells. The interlobular capillaries are much 

 distended with blood. No areas of free blood extravasation are 

 seen. The mucosa of the gall bladder is practically normal, 

 although the walls of the organ are intensely cedematous. The 

 cedema and extravasated blood have infiltrated the connective tissue 

 so extensively that the fibers form a loose open network, the meshes 

 of which are filled with numerous pale, red blood corpuscles. 

 From the erytlirocytes the infiltrating fluid has extracted almost 

 all of the hemoglobin, so that they do not stain well with eosin. 

 The veins in the mucosa of the stomach are much dilated and are 

 frequently surrounded by small periphlebitic areas of cell infiltra- 

 tion. The congestion of the veins of the submucosa is continued 

 into the interglandular capillaries, from which blood extravasation 

 has infiltrated the tissue. Some of the extravasated blood is found 

 between the fixed cells of the mucosa, some of it being deposited 

 free on the surface. The picture seen in these sections is very much 

 like that found, in a menstruating endometrium. Sections from 

 the lungs, the heart, and the pancreas do not show any pronounced 

 changes. The hemorrhagic areas in sections from the different 

 organs were carefully examined for plague bacilli, but none were 

 found. Hence the changes must be looked upon as due to toxic 



