89 



mononiiclars. Others of this type show a swollen protoplasm with 

 either a poorly stained niiclens or one not stained at all. Bodies 

 are also present which may best be described as cell shadows, which 

 contain a rather fine, dark broA\'n, grannlar pigment, probably 

 a hemoglobin derivative. Coarse and fine granular, yellowish-brown 

 pigment is also seen between the cells. Typical plasma cells, 

 mononuclears with- a large hyaline protoplasm, and polynuclears are 

 not numerous. Eosinphiles are not seen. A few small vessels 

 contain hyaline fibrin thrombi; but there is no extravascular fibrin 

 reticulum present. Plague bacilli are found in dense masses, in 

 which only a few autochthonous tissue cells are left and those greatly 

 changed. From the dense clumps the bacilli infiltrate the spaces 

 between the cells in those parts of the sections where more cells 

 are still present. Spleen: The capsule shows no marked changes; 

 the trabecule, on the other hand, generally show hyaline swelling 

 and loss of nuclei. A small trace of an original Malpighian body 

 is seen here and there. Most of the corpuscles have disappeared 

 in consequence of necrotic processes, or at least their boundaries 

 have become quite indistinct, the follicle losing itself in a dense 

 mass of changed nucleated cells and degenerating erythrocytes. 

 The pulp spaces are indistinguishable on account of their great 

 engorgement with blood. Everywhere there is present a homo- 

 geneous mass with vacuoles, which are more or less occupied with 

 nucleated cells. The homogeneous matrix, which stains well ^vdth 

 eosin (in some places it takes the stain particularly well), is very 

 probably a product of degenerated, agglutinated, confluent red 

 blood corpuscles. In fact, in some places the more or less homo- 

 geneous, eosin-staining material is undoubtedly composed of red 

 blood cells. The cells found in the vacuoles of the hemogeneous 

 matrix are mostly polynuclears. Next in order of frequency come 

 small mononuclear cells. These show more marked changes than 

 the former, namely, poorly stained or very pyknotic or fragmented 

 nuclei. Eosinophiles are also found. Plasma cells and large hyaline 

 mononuclears are not seen in the spleen. Bacilli in snuill numbers 

 are scattered all over the sections, and in places are found in more 

 numerous groups. A few small vessels contain hyaline thrombi. 

 Kidneys: All vessels are much dilated and engorged. The intersti- 

 tial connective tissue is oedematous and shows a decided increase in 

 some places, although not so great as that seen around the capsules 

 of Bowman. Tn general the glomerular capillaries are like the 



