120 



groups in some of the glomeruli; they are also observed both in the 

 capillaries and between them. A very few isolated organisms are 

 encountered in the interstitial connective tissue between the tubules. 

 The liver parenchyma cells show fine and coarse vacuolation. Inter- 

 lobular inflammatory foci composed of small mononuclear cells are 

 seen here and there, but the interlobular fibrous connective tissue is 

 not increased. The interlobular capillaries and the vessels in 

 general are much engorged with numerous, densely crowded red 

 blood corpuscles. In a number of places inside the capillaries 

 groups of plague bacilli are seen. However, this infection of the 

 hepatic blood system is not general, the bacilli being confined to 

 a number of more or less isolated spots. A good deal of granular 

 bile pigment is found scattered throughout the hepatic tissue. 

 The pulmonary sections show greatly engorged capillaries and 

 veins, with an increased number of leucocytes in some of the latter. 

 In a number of places the capillaries contain groups of plague 

 bacilli. The alveoli contain desquamated epithelia and here and 

 there a little extravasated blood. Otherwise there are no grave 

 changes. N'o plague bacilli are seen in the alveoli. Spleen: The 

 follicles are hazy in outline, the boundaries of the pulp spaces are 

 indistinct and the latter are densely crowded with red blood cor- 

 puscles. The cells forming the follicles contain many large mono- 

 nuclears with a large hyaline protoplasmic body. A considerable 

 number of nuclei in the large hyaline mononuclears show a general 

 pyknosis or lumping of the chromatin into dense granular masses. 

 Plague bacilli generally are disseminated in moderate numbers 

 throughout the splenic tissue, and in some parts of the pulp in 

 larger groups. A veiy few of the smallest vessels contain hyaline 

 fibrin thrombi. The inguinal lymph glands show much dilated 

 and engorged vessels and an increase in the connective tissue at 

 the hilum. Plague bacilli are seen here and there in little isolated 

 groups. In the gastric mucosa the hemorrhagic spots are situated 

 directly below the surface. The extravasation has taken place 

 from the interglandular capillaries. These hemorrhagic areas are 

 found to contain fairly numerous plague bacilli. It is perhaps 

 possible that the portal of entrance of the plague bacillus in this 

 case was the hnigs. However, since no areas of consolidation were 

 found and the infection of the lungs was quite moderate, the case 

 has been classified as one of primary plague septicaemia. 



