STRUCTURE 47 



they occupy the whole of the periphery of the nodule. 

 They appear to be very densely crowded together and 

 this is the more obvious on account of their darkly 

 staining predominant nuclei. The cytoplasm does not 

 stain well with eosin. Whatever the small lymphocytes 

 may be in the blood, they are undoubtedly phagocytic 

 in the subepithelial lymphatic glands as will be shown 

 subsequently. 



These two classes of cells have been termed macro- 

 phages and microphages (Ruffer), or endothelial cells 

 and lymphocytes. But I prefer to call them large and 

 small glandular lymphocytes. Glandular lymphocyte 

 is a somewhat clumsy name, but although probably 

 the large and small glandular lymphocytes in the 

 glands become the large and small lymphocytes in the 

 blood, it seems incautious to assume it too dogmatically 

 in the nomenclature. 



The large glandular lymphocytes are, probably, en- 

 dothelial in nature. They have been said to line the 

 reticular meshwork and to correspond with the endo- 

 thelial wall of a lymphatic vessel. It is generally 

 assumed, following Flemming, that, as mitotic figures 

 are frequently visible, the large glandular lymphocytes 

 by division give rise to the small glandular lympho- 

 cytes. The large lymphocytes can reproduce them- 

 selves as large lymphocytes, however, as is seen in 

 Hodgkin's disease (Lymphadenoma). Perhaps the 

 large glandular lymphocyte divides to form either small 

 or large glandular lymphocytes according to its imme- 

 diate environment. Some have described the small 

 glandular lymphocyte as growing into a large glandular 

 lymphocyte, but I think this very improbable. A few 

 of the large glandular lymphocytes escape from the 

 nodules and eventually enter the blood where they form 

 some, at least, of the infrequent large lymphocytes 

 there found. 



