172 PASTEUR AND HYDROPHOBIA III 



efficacious, there is a natural reluctance to change 

 any of its empirical details, but that further experi- 

 ment with animals may lead to modification in the 

 direction indicated by his queries. On the other 

 hand, it is admitted by all who have occupied them- 

 selves with the subject that there is still a vast deal 

 to be ascertained experimentally in regard to the 

 whole question of vaccins and immunity. A curious 

 commentary on M. Bouchard's anticipations is found 

 in the fact that the Eussian physicians have modified 

 Pasteur's system in the opposite direction. They 

 carry on the series of inoculations till medullas of 

 only two days, and in some cases fresh medullas not 

 twenty-four hours old, are reached. The results of 

 this intensive treatment are said to be extremely 

 satisfactory, giving less than 1 per cent of deaths. 

 The Therapeutique des Maladies Infectieuses, Anti- 

 sepsie of Professor Bouchard, published in Paris in 

 1889, contains the most luminous exposition of the 

 whole subject of vaccination and immunity in refer- 

 ence to Bacteria with which I am acquainted. Those 

 who may have been stimulated by the foregoing 

 remarks to a desire for further information on these 

 topics cannot do better than peruse M. Bouchard's 

 admirable work. 



