BACILLUS OF HOG CHOLERA. 



Detmers (1880). 

 BILLING'S SWINE PLAGUE BACILLUS. BACTERIUM OF HOG CHOLERA 



(SALMON AND SMITH). 



Origin. In the blood, organs and intestinal contents 

 of swine that died of hog cholera. 



Form. Short, small rods, resembling those of chicken 

 cholera. On some media, as gelatin, it may form long 

 rods. Occurs single or in pairs. 



Motility. Is actively motile. Has long, wavy flag- 

 ella. Shows no motion in serum or in blood. 

 Sporulation. Not observed. 



Anilin Dyes. At first impart a bi-polar stain, but 

 on sufficient exposure the entire rod is colored. Is not 

 stained by Gram's method. 

 Growth. Is fairly rapid. 



Plates. In a couple of days colonies develop on gelatin plates. The 

 deep colonies are very small, yellowish-brown and spherical. The surface 

 colonies spread slightly. No liquefaction. 



Stich Culture*. &\\o\v along the line of inoculation a white line or row 

 of colonies, while on the surface of the gelatin a thin, very slowly spreading 

 growth forms. 



Streak Cultures Qn agar forms a moist grayish-white growth without 

 any special characteristics. On potatoes a straw yellow growth develops, re- 

 sembling somewhat that of glanders. 



Oxygen requirements. Is a facultative anaerobe. 



Temperature. Grows well at ordinary temperature. 

 Best at about 37 0. 



Behavior to Gelatin. Does not liquefy. 



Attenuation. Artificial cultures retain their viru- 

 lence apparently indefinitely, same as the anthrax bacillus. 



Immunity. Can be produced experimentally by 

 inoculation with filtered cultures ; with repeated small 

 doses of blood, previously heated to 54-58 C , from infec- 

 ted rabbits. 



Pathogenesis. Hog, mice, rabbits and guinea-pigs 

 are highly susceptible ; pigeons are less susceptible, while 

 chickens, sheep and calves are immune. -\ c.c. of bouillon 

 culture injected subcutaneously into rabbits kills in about 

 four days. Bacilli distributed everywhere. 



Infection. May result through the food, also by in- 

 oculation through wounds. 



