THE ANIMAL PARASITES OF MAN 



sequence of the pain they give rise to, the patients avoid using the 

 voluntary muscles as much as possible. At the commencement of the 

 disease there are more or less severe attacks of diarrhoea, which, together 

 with the fever and abdominal pain arising at this period, can be ascribed 

 to the boring female trichinellae and the wounds they make in the intes- 

 tinal wall. When the brood commences to migrate small cedemas appear, 

 especially under the eyes. 



The muscular fibres attacked degenerate, the transverse stria- 

 tion at first disappearing ; the fibres then assume a granular 

 appearance, the nuclei multiply and become enlarged, and are 

 surrounded by an area of granular material, which stains more 

 deeply than the remaining contents of the sarcolemma. Two or 

 three weeks after infection, the spirally rolled-up trichinellae have 



V.- 



FIG. 208. Calcified trichinella in 

 the muscular system of a pig ; the 

 capsules are not calcified. (After 

 Ostertag.) 



FIG. 209. Various phases of the 

 calcification of trichinella of the 

 muscles, which starts at the poles 

 of the capsule. 



grown to O'8 1*0 mm., and in their vicinity the muscular 

 fibre is swollen, spindle-shaped, and the sarcolemma is glassy 

 and thickened. The inflammation also extends to contiguous 

 fibres, especially to the intra-muscular tissue, which prolifer- 

 ates greatly, especially in the vicinity of the degenerated fyoces. 

 While the latter become more and more absorbed, the capsule 

 is formed by the inflamed connective tissue, which, penetrating 

 into the glassy and thickened sarcolemma by way of the poles of 

 the spindle, takes its place and forms the cystic membrane. 

 The cysts are lemon-shaped and usually lie with their longitudinal 

 axis in the direction of the muscular fibres ; on an average they 

 measure 0^4 mm. in length by 0*25 mm. in breadth. 



