UDDER-STAPHYLOMYCOSIS 59 



The local condition as a rule is confined to one quarter 

 but may, however, be extended to more quarters, especially 

 by highly virulent organisms. 



The primary lesion varies with the virulence of the 

 organism and the condition of the udder. Shortly after 

 parturition, especially, a primary lesion can develop into 

 diffuse necrosis of the infected quarter. 



In this manner the infection manifests its relation with 

 Nocard's staphylomycosis of sheep : " Mammite gangre- 

 neuse de la brebis." 



The quantity and quality of the inflammation varies 

 with the primary lesion. The infection appears to have 

 no tendency toward chronicity. 



Secondary infection may occur in the form of strep- 

 tomycosis, colibacillosis, pyobacillosis and tuberculosis. 



These secondary infections are marked as a rule by the 

 predominant staphylococci. Later, where the staphylococ- 

 cus has completely run its course, the condition can be 

 continued as a chronic infection as streptomycosis, pyoba- 

 cillosis, or tuberculosis. 



A saprophytic invasion is common following a severe 

 primary lesion, but otherwise infrequent. 



The General Condition. — Infection of the blood ap- 

 pears to occur very infrequently. 



The intoxication varies with the virulence of the or- 

 ganism and the condition of the udder, i.e.^ with the quality 

 and quantity of the primary lesion. 



The fatal septic intoxication may easily follow diffuse 

 necrosis of the infected quarter, especially if gangrene 

 develops. 



Termination. — The condition may be fatal. The 

 course is always acute and varies from a few days to three 

 weeks. If the infection is removed by the inflammation 

 the condition usually develops into a low-grade sclerosis. 



Clinical Symptoms. — The condition is always acute, 



