198 



These results were confirmed at the Tokio Institute for Infectious 

 Diseases by Shibayama, by biological and immunizing tests. 



Outbreak 2. On December 7, 1905, a peasant of a village in the 

 Province of Miyaki brought home some mouse virus mixed with meal 

 in cakes. This being mistaken for "mochi" was eaten about 2 p. m. 

 the next day by two little girls, 3 and 8 years old, respectively, and 

 their grandfather, 61 years old. 



The man and the 8-year-old girl became sick at 9 p. m. the same 

 day and the other child at about 3 p. m. on December 9. The 

 symptoms in all cases were those of severe gastro-enteritis, as de- 

 scribed under outbreak 1. 



The man died December 12, the 8-year-old child died" on the 10th; 

 the 3-year-old child recovered after several days' illness. These 

 three alone ate of the virus and no other persons in the house became 

 sick. 



No bacteriological examination was practicable. 



Outbreak 3. In a village of the Province of Iskawa, on April 22, 

 1906, a lot of rat poison was prepared by mixing agar cultures of the 

 mouse-typhoid bacillus with meal and water in a large wooden bowl. 



On April 24 there was a festival in the village at which about 170 

 persons were served with 240 pounds of rice, which, after being cooked, 

 was kneaded into cakes in a wooden bowl. About 80 pounds of this 

 rice was so kneaded in the bowl previously used for preparing the 

 rat poison. Twenty to twenty-four hours later 120 people who had 

 eaten of the rice became ill with the already described symptoms of 

 gastro-enteritis, of mild type among the strong but severe among 

 the children and old people. Eighty-nine cases came under medical 

 treatment. There were no deaths, but a number of cases were con- 

 fined to bed for a week or more; mild cases recovered in one to three 

 days. 



No bacteriological examination was made, but the physicians and 

 town officials were unanimously of the opinion that the rat virus 

 was the cause of the outbreak. 



Outbreak 4. A peasant of the province of Niigata brought home 

 on May 14, 1906, some rat virus (cultures of mouse- typhoid bacilli 

 mixed with meal) which he laid away. Two of his grandchildren 

 a boy of 5 and a girl of 7 together with the 4-year-old daughter of 

 a neighbor, found and ate the rat virus. The next day all three 

 children became ill with severe gastro-enteritis, of which the 4-year- 

 old child died on the third day. The others recovered after several 

 days of medical treatment. 



Outbreak 5. On May 16, 1906, a peasant in the province of Jama- 

 gata brought home some rat virus (6 c. c. cultures of mouse-typhoid 

 bacillus mixed with meal), which was accidentally mixed with the 

 feed given to a healthy horse next morning. The same evening the 



