THE COENEA 321 



Lundsgaard's case was one of atypical hypopyon - keratitis of 

 moderate severity ; the others were severe non - purulent ulcers. 

 Lundsgaard and Stower found Hcfa rosa in pure culture. The 

 American authors did not succeed in an exact identification, as their 

 organism was mixed with Sarcince, bacilli, and Diplobacilli. 



This Hcfa (Lundsgaard) at first grew at brood temperature, and, 

 just as in Stower's experiments, produced nodules in the iris, from 

 which weeks later the Hefa could again be grown. In the vitreous a 

 white membrane was formed. In the cornea of a rabbit a benign 

 rapidly healing inflammation occurred without a hypopyon. After 

 continued cultivation the optimum temperature sank, and in this 

 particular the strain which Lundsgaard grew took on the charac- 

 teristics of the common non-pathogenic Hcfa rosa. 



These findings remain isolated, 1 so that there can be no great import- 

 ance ascribed to the Hcfa in the etiology of corneal inflammations. 

 The authors quoted consider that HeUe were very probably the cause 

 of the condition present in their cases. 



Klein has obtained a nodular inflammation of the conjunctiva and iris 

 through endogenous channels ; and Stock carried out in my laboratory 

 a full experimental and microscopic research into the nature of these 

 peculiar haematogenous inflammations (cf. Ophth. Congr. Heidel., 

 1907, and Ziegler's Bcitmgc z. Path. Anat., 1908). 



ZUP Nedden's Bacillus of Marginal Uleeration. 

 (Cf. PLATE III., FIG. IT'.) 2 



Superficial corneal ulcers, marginal in position, develop by the 

 breaking down of infiltrates ; these may be single, or multiple when 

 they tend by their confluence to the formation of trough-shaped 

 ulcers. In the floor of such marginal ulcers, and more rarely in 

 centrally - placed processes, Zur Nedden 3 found a bacillus which 

 differed from any known organism. From its frequent occurrence, 

 and its pathogenicity for the cornea of rabbits, he rightly considered 

 it to be the cause of these ulcers. 



The bacillus has been found in the same hospital in a case of neuro- 



1 In the sections of a so-called fibroma of the cornea, stained with Busse's Hefa-st&in, 

 Schiruier found fuchsinophile granules -which presented the appearance of Hefcc (Beit. c. 

 Aug., 1899, xxxi.). This peculiar finding is analogous to that in the chronic granulation 

 tissue tumours which can be produced by the action of the pathogenic Hefce. 



2 The drawing is from a direct preparation from an ulcer ; the preparation was sent me 

 by Dr. Zur Nedden. 



3 A.f. 0. 1904, Bd. lix., S. 360 ; also K. M. f. A., 1906, xliv., Bd. i., S. 479. 



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