30 THE CHEMICAL CONSTITUTION OF THE PROTEINS 



POLYPEPTIDES SYNTHESISED BY METHOD I. 



Glycine ester 



Alanine ester - 



Leucine ester - 



Diaminopropionic acid ester 



Histidine ester - 



Lysine ester - 



Arginine ester 



Serine ester 



Isoserine ester 



Tyrosine methyl ester - 



Aspartic acid methyl ester - 



Simplt Polypeptides. 



glycine anhydride - glycyl-glycine. 



alanine anhydride > alanyl-alanine. 



leucine anhydride -* leucyl-leucine. 



-> diaminopropionic acid anhydride. 



histidine anhydride 

 lysine anhydride 



serine anhydride 



histidyl-histidine. 

 lysyl-Iysine. 

 arginyl-arginine (?) 

 seryl-serine. 

 isoseryl-iso serine. 

 tyrosyl-tyrosine. 



diketopiperazine diacetic diamide 

 by action of ammonia. 



tyrosine anhydride 

 aspartic acid anhydride 

 2-5-diketopiperazine, 3-6- 



diacetic acid 



pentaglycyl-glycine ester - pentaglycyl-glycine. 

 octaglycine anhydride (?) 

 1-Alanyl-glycyl-glycine methyl ester -* 1-alanyl-diglycyl-l-alanyl-glycyl-glyctne. 



Diglycyl-glycine methyl 

 ester 



leucyl-alanine anhydride 

 leucyl-proline anhydride 



I from dipeptide. 



Chloracetyl alanine ester 



Chloracetyl tyrosine ester 



Glycyl-1-phenylalanine ester 

 l-Phenylalanyl-glycine ester 



Leucyl-glycine ester 

 Glycyl -aspartic acid ester 



Phenylalanyl-glycine ester 

 Valyl-glycine ester 

 Valyl-alanine ester 

 1-Valyl-d-valine ester 



Mixed Polypeptidt*. 

 glycyl-alanine anhydride 

 glycyl-1-tyrosine anhydride 



glycyl-1-phenylalanine anhydride 



leucyl-glycine anhydride 

 glycyl-aspartic acid anhydride 

 leucyl-alanine anhydride 

 phenylalanyl-glycine anhydride. 



glycyl-alanine. 

 alanyl-glycine. 

 glycyl-1-tyrosine. 

 1-tyrosyl-glycine. 



leucyl-glycine. 

 glycyl-leucine. 



leucyl-alanine. 

 alanyl-leucine. 



- valyl-glycine anhydride. 



- valyl-alanine anhydride. 



-> /ranj-valine anhydride. 

 Iodopropionyl-1-tryptophane methyl ester - alanyl-tryptophane anhydride. 

 Cilycyl-1-isoleucine-methyl ester - glycyl-1-isoleucine anhydride. 

 1-Leucyl-d-isoleucine methyl ester - l-leucyl-d-isoleucine anhydride. 

 Glycyl-aminostearic acid ester > glycyl-aminostearic acid anhydride. 

 Leucyl-/3-aminobutyric acid ester - leucyl-/3-aminobutyric acid anhydride. 



Glycyl-d-valine methyl ester 

 d-Alanyl-d valine methyl ester 

 1-Leucyl-d-valine methyl ester 

 Prolyl-glycine ester 

 Prolyl-leucine ester 

 Glycyl-serine methyl ester 

 Ala ny I -serine methyl ester 



glycyl-d-valine anhydride, 

 d-alanyl-d-valine anhydride. 

 1-leucyl-d-valine anhydride, 

 prolyl-glycine anhydride, 

 prolyl-leucine anhydride, 

 glycyl-serine anhydride, 

 alanyl-serine anhydride. 



Glycyl-aminobutyric acid methyl ester - glycyl-aminobutyric acid anhydride. 



