THE MICROSCOPE IN PATHOLOGY. 



233 



FIG. 184. 



and function is usually less interfered with. They include 

 fatty, amyloid, calcareous, and pigmentary infiltration, etc. 



THE METAMORPHOSES. 



1. Fatty Degeneration. 



The metamorphosis of the protoplasm of the cell is 

 marked by the occurrence of fat- 

 globules in its interior. Its pro- 

 gress may be illustrated by de- 

 generating epitheliun in dropsy 

 of the pericardium (Fig. 184). 



The granular corpuscles were 

 formerly known as the " inflam- 

 matory " or u exudation corpus- 

 cles," or " corpuscles of Gluge." 

 They are identical in structure 

 with colostrum-corpuscles thrown 

 off by the mammary gland after 

 parturition, and the last act of 

 fatty degeneration is considered 



as a lactification. The fatty detritus may be absorbed as 

 milk, or if not absorbed it is partly saponified and partly 

 separated in solid form, as margarin, etc. Finally there is 

 an abundant deposition of crystals of cholesterin (Fig. 185). 



This substance is found nor- 

 mally in the brain and spinal 

 marrow in quite large propor- 

 tions, and in solution in the 

 bile. It forms rhombic tablets, 

 lying in heaps, with their long 

 sides parallel. 



In some cases when the fatty 

 detritus is not absorbed it 

 undergoes a change into a 

 crumbling material somewhat 

 resembling cheese, and hence called 'caseation. This ap- 



The fatty metamorphosis. Epi- 

 thelium of the pericardium in 

 dropsy of pericardium, a. Cells 

 which still show the normal form 

 and arrangement. First appear- 

 ance of fat-globules, b. Granular 

 globules, the one with a nucleus 

 still visible, c. Granular globules 

 disintegrating to fatty detritus. 

 After KINDFLEISCH. 



FIG. 185. 



Crystals of cholesterin. After VIR- 

 cuow. 



