262 THE MICROSCOPIST. 



some of the cells undergo fatty degeneration and are ab- 

 sorbed, others are removed by the lymphatics, and the 

 tissue returns to its normal condition. 



If the inflammation does not end in resolution, after a 

 diminution of intensity, there may be an organization of 

 many of the new cells into a form of fibrillated tissue, as 

 in the healing of wounds by u the first intention," and in 

 many chronic inflammations of the liver, kidney, etc. In 

 this cicatricial tissue the cells become spindle-shaped or 

 elongated, with tapering ends. Sometimes, according to 

 Green, a sort of adenoid tissue results, consisting of 

 meshes of fibrillated material inclosing lyrnphoid cells. 



After suppuration, organization takes place by granu- 

 lation or the "second intention" It takes place wherever 

 the injured tissue presents a free surface to the air, as in 

 an ulcer, or in a wound left open, etc. (Fig. 213). The 

 young cells of the superficial layer develop into granula- 

 tion tissue, which forms little papilliform nodules or granu- 

 lations. The form of these granulations seems determined 

 by the new capillary bloodvessels which grow rapidly in 

 the new tissue. The deeper layers of the tissue gradually 

 develop into fibrillated tissue, while the cells on the sur- 

 face of the granulations and transuded liquid from the 

 vessels are discharged as pus. The first formation of epi- 

 thelium seems to consist of pus-corpuscles not thrown off, 

 yet the influence of the neighboring normal epithelium is 

 seen in the proliferating margins, as w^ell as in the effect 

 of skin-grafting, as it is called, on the surface of an ulcer. 

 The new epithelium alwa3 T s remains thin and dry. 



PATHOLOGICAL NEW FORMATIONS. 



Increased nutrition leads not only to the enlargement 

 of the component elements of a tissue, but also to the 

 production of new elements by proliferation of bioplasm 

 constituting new formations. These may be either in- 

 flammatory or non-inflammatory growths, occurring as 



