284 THE MICROSCOPIST. 



cell proliferation in the interstitial and encapsuling con 

 nective tissue of the sebaceous and sweat glands (Fig. 

 231). If the skin appears normal, or there is a moderate 

 scaling till the lupus elements are resorbed, and there 

 is left behind a smooth or radiating cicatrix, it is called 

 lupus non exedens. Lupus exedens, or rodens, is ulcerative. 

 4. Lepra Elephantiasis Grcecorum. Leprosy formerly 

 prevailed all over Europe, but is now confined in that di- 

 vision of the globe to Iceland, Norway, the northern 



FIG. 231, 



Lupus. Section showing the transition of the healthy skin into the highest degree of 

 infiltration, a. Acinous alveoli, b. Germinal tissue of the lupus nodule, c. Metaplastic 

 hair-follicle and sebaceous gland. 1-10. After RINDFLEISCH. 



provinces of Russia, and the borders of the Caspian and 

 Mediterranean seas. It still remains in Asia Minor, 

 Arabia, Egypt, India, China, and the Hawaiian Islands. 

 It is rarely cured, and generally destroys life by some sec- 

 ondary affection, as anaemia, diarrhoea, pneumonia, menin- 

 gitis, etc. 



L. tuberculosa, the common form, is characterized by a 

 nodular formation in the skin and other organs. The 

 microscope shows these to consist usually of round granu- 

 lar cells with granular albuminous intercellular substance 

 (Fig. 232). 



These nodules soften and form ulcers, yielding a thin 

 sanious pus, which dries to a brownish crust. 



In L. ancesthetica the nodules are absent, but there is 



