VACCINTATION AGAINST SMALLPOX 165 



On the seventh day he complained of uneasiness in the 

 axilla, and on the ninth he became a little chilly, lost his 

 appetite, and had a slight headache. During the whole of 

 this day he was perceptibly indisposed, and spent the night 

 with some degree of restlessness, , but on the day following 

 he was perfectly well. 



The appearance of the incisions in their progress to a 

 state of maturation were much the same as when produced 

 in a similar manner by variolous matter. The only difference 

 which I perceived was in the state of the limpid fluid arising 

 from the action of the virus, which assumed rather a darker 

 hue, and in that of the efflorescence spreading round the in- 

 cisions, which had more of an erysipelatous look than we 

 commonly perceive when variolous matter has been made 

 use of in the same manner; but the whole died away (leaving 

 on the inoculated parts scabs and subsequent eschars) with- 

 out giving me or my patient the least trouble. 



In order to ascertain whether the boy, after feeling so 

 slight an affection of the system from the cow-pox virus, was 

 secure from the contagion of the smallpox, he was inoculated 

 the 1st of July following with variolous matter, immediately 

 taken from a pustule. Several slight punctures and incisions 

 were made on both his arms, and the matter was carefully 

 inserted, but no disease followed. The same appearances 

 were observable on the arms as we commonly see when a 

 patient has had variolous matter applied, after having either 

 the cow-pox or smallpox. Several months afterwards he 

 was again inoculated with variolous matter, but no sensible 

 effect was produced on the constitution. 



Here my researches were interrupted till the spring of 

 the year 1798, when, from the wetness of the early part of 

 the season, many of the farmers' horses in this neighbour- 

 hood were affected with sore heels, in consequence of which 

 the cow-pox broke out among several of our dairies, which 

 afforded me an opportunity of making further observations 

 upon this curious disease. 



A mare, the property of a person who keeps a dairy in a 

 neighbouring parish, began to have sore heels the latter end 

 of the month of February, 1798, which were occasionally 

 washed by the servant men of the farm, Thomas Virgoc, 



