168 EDWARD JK.NNER 



cumstances in the inoculated smallpox) the complaint sub- 

 sided without giving much trouble. 



Hannah Excell, an healthy girl of seven years old, and 

 one of the patients above mentioned, received the infection 

 from the insertion of the virus under the cuticle of the arm 

 in three distinct points. The pustules which arose in con- 

 sequence so much resembled, on the twelfth day, those 

 appearing from the infection of variolous matter, that an 

 experienced inoculator would scarcely have discovered a 

 shade of difference at that period. Experience now tells me 

 that almost the only variation which follows consists in the 

 pustulous fluids remaining limpid nearly to the time of its 

 total disappearance; and not, as in the direct smallpox, be- 

 coming purulent. 



CASE XXII. From the arm of this girl matter was taken 

 and inserted April I2th into the arms of John Macklove, one 

 year and a half old, Robert F. Jenner, eleven months old, 

 Mary Pead, five years old, and Mary James, six years old. 



Among these, Robert F. Jenner did not receive the in- 

 fection. The arms of the other three inflamed properly and 

 began to affect the system in the usual manner; but being 

 under some apprehensions from the preceding cases that a 

 troublesome erysipelas might arise, I determined on making 

 an experiment with the view of cutting off its source. 

 Accordingly, after the patients had felt an indisposition of 

 about twelve hours, I applied in two of these cases out of 

 the three, on the vesicle formed by the virus, a little mild 

 caustic, composed of equal parts of quick-lime and soap, and 

 suffered it to remain on the part six hours." It seemed to 

 give the children but little uneasiness, and effectually answer- 

 ed my intention in preventing the appearance of erysipelas. 

 Indeed, it seemed to do more, for in half an hour after its 

 application the indisposition of the children ceased." These 

 precautions were perhaps unnecessary, as the arm of the 

 third child, Mary Pead, which was suffered to take its com- 

 mon course, scabbed quickly, without any erysipelas. 



11 Perhaps a few touches with the lapis septicus would have proved 

 equally efficacious. 



13 What effect would a similar treatment produce in inoculation for the 

 smallpox? 





