VACCINATION AGAINST SMALLPOX 169 



CASE XXIII. From this child's arm matter was taken 

 and transferred to that of J. Barge, a boy of seven years old. 

 He sickened on the eighth day, went through the disease 

 with the usual slight symptoms, and without any inflamma- 

 tion on the arm beyond the common efflorescence surround-: 

 ing the pustule, an appearance so often seen in inoculated 

 smallpox. 



After the many fruitless attempts to give the smallpox to 

 those who had had the cow-pox, it did not appear necessary, 

 nor was it convenient to me, to inoculate the whole of those 

 who had been the subjects of these late trials; yet I thought 

 it right to see the effects of' variolous matter on some of 

 them, particularly William Summers, the first of these 

 patients who had been infected with matter taken from the 

 cow. He was, therefore, inoculated with variolous matter 

 from a fresh pustule ; but, as in the preceding cases, the 

 system did not feel the effects of it in the smallest degree. 

 I had an opportunity also of having this boy and William 

 Pead inoculated by my nephew, Mr. Henry Jenner, whose 

 report to me is as follows : " I have inoculated Pead and 

 Barge, two of the boys whom you lately infected with the 

 cow-pox. On the second day the incisions were inflamed and 

 there was a pale inflammatory stain around them. On the 

 third day these appearances were still increasing and their 

 arms itched considerably. On the fourth day the inflam- 

 mation was evidently subsiding, and on the sixth day it 

 was scarcely perceptible. No symptom of indisposition 

 followed. 



"To convince myself that the variolous matter made use 

 of was in a perfect state I at the same time inoculated a 

 patient with some of it who never had gone through the cow- 

 pox, and it produced the smallpox in the usual regular man- 

 ner." 



These experiments afforded me much satisfaction; they 

 proved that the matter, in passing from one human subject to 

 another, through five gradations, lost none of its original 

 properties, J. Barge being the fifth who received the infection 

 successively from William Summers, the boy to whom it was 

 communicated from the cow. 



